AI Article Synopsis
- Chrysotile-asbestos fibers and zeolite particles cause chromosome damage in human lymphocytes and mouse cells, indicating potential mutagenic effects.
- The cytogenetic response varies based on the duration of exposure to these materials.
- Antioxidants like SOD can mitigate the harmful effects of chrysotile-asbestos, while catalase may enhance the damage caused by zeolite particles, suggesting different mechanisms at play.
Article Abstract
It has been established that chrysotile-asbestos fibers and zeolite particles induce chromosome aberrations in human lymphocytes from whole blood cultures, peritoneal fluid cells and bone marrow cells of mice. It is shown that the level of cytogenetic response from the intraperitoneal administration of chrysotile-asbestos fibers and zeolite particles depends on the time of their exposure. Further, it is shown that SOD eliminates the cytogenetic effect of chrysotile-asbestos fibers, while catalase inhibits that of zeolite particles. Recommendations concerning testing for the mutagenic properties of mineral fibers and particles are given, and possible mechanisms of their damaging effects are discussed.
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| http://dx.doi.org/10.1016/0165-1218(93)90019-a | DOI Listing |
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