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Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients.
Clin Epigenetics
January 2025
Center of Oncocytogenomics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University in Prague, U Nemocnice 499/2, 128 00, Prague, Czech Republic.
Background: Glioblastoma is the commonest malignant brain tumor and has a very poor prognosis. Reduced expression of the MGMT gene (10q26.3), influenced primarily by the methylation of two differentially methylated regions (DMR1 and DMR2), is associated with a good response to temozolomide treatment.
View Article and Find Full Text PDFRandomized studies in China show that studying and promoting civic honesty needs to consider local norms.
Sci Rep
January 2025
Hangzhou Fancha Technology, Hangzhou, China.
Civic honesty is a crucial behavior that policymakers and business leaders strive to promote among citizens and employees. We conducted online and field experiments in China adapting the setting of a recent research which employed an innovative design to study civic honesty behavior around the globe. Results show that the psychological mechanism underlying lost-wallet reporting behavior in China is somewhat different from what has been suggested in the literature.
View Article and Find Full Text PDFComparison of Pharmacokinetics of Long-Acting Local Analgesics: CPL-01, a Novel Extended-Release Ropivacaine, Demonstrates Consistent and Predictable Exposure Compared with Liposomal Bupivacaine.
Clin Drug Investig
January 2025
Cali Biosciences, US, LLC, San Diego, CA, USA.
Background And Objective: There is a significant medical need for improved long-acting local anesthetics to decrease postsurgical pain and reduce postoperative opioid use. While ropivacaine is considered a safer local anesthetic than bupivacaine, no long-acting ropivacaine formulation is currently marketed. Available formulations of bupivacaine show inconsistent pharmacokinetics (PK) among different surgical models, and inconsistency in PK may lead to a reluctance to use the medication owing to fear of local anesthetic systemic toxicity (LAST) or unreliable efficacy.
View Article and Find Full Text PDFRecurrence after surgery for clear cell and papillary renal cell carcinoma: Head-to head comparison of validated risk scores.
Urol Oncol
January 2025
Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Introduction: The American Urology Association (AUA) recently introduced in their guidelines a subtype-agnostic, 4-tiered risk classification score to assess oncologic outcomes after surgery in patients with localized renal cell carcinoma (RCC). We provide a head-to-head comparison of the AUA score with 3, internationally validated and EAU recommended, histological-specific models.
Materials And Methods: We retrieved from a prospectively-maintained database 2,560 surgically-treated patients with localized RCC in a single high-volume European center (1987-2023).
How do multiple deprivations in nuanced urban and rural settings affect health differently in South Africa? Evidence from NIDS data, 2017.
BMJ Open
January 2025
Economics, University of KwaZulu-Natal - Durban Campus, Durban, KZN, South Africa
Introduction/objective: Previous research on socioeconomic factors influencing health outcomes has often centred on the urban-rural divide, overlooking the nuanced variations within these categories. This study enhances our understanding by moving beyond traditional comparisons to examine the specific impacts of multiple deprivations on self-rated health across traditional authority areas, rural formal areas, urban informal areas and urban formal areas. By doing so, it captures the unique challenges and health implications associated with varying deprivation levels within these diverse contexts.
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