Two types of thyroid biochemical abnormalities (TBA) are observed in AIDS. The unspecific TBA are similar to TBA reported in the Euthyroid Sick Syndrome. An increased serum TBG of unknown origin and a decreased circulating rT3 are the most specific TBA of AIDS. The latter abnormality may be in relation with an elevated level of TNF. The frequency of serum antithyroid antibodies seems higher than in control groups. Opportunistic infections of the thyroid gland or destruction of the thyroid by Kaposi's sarcoma are also reported in AIDS.
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