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Characteristics of open eye injuries in the Beirut Port explosion.
Injury
September 2021
Ophthalmology Department, Eye and Ear Hospital International, Faculty of Medecine, Holy Spirit University, Kaslik, Lebanon.
Introduction: On the 4 of August 2020 an ammonium nitrate explosion took place at the Port of Beirut in Lebanon. The aim of this study was to present the open eye injuries caused by the Beirut Port blast, and to describe their characteristics and visual outcomes at 6 months.
Methods: Patients who suffered from open globe injuries during the Beirut port explosion were recruited.
Development and validation of a score for emergency intervention in patients with acute renal colic secondary to ureteric stones.
Arab J Urol
May 2020
Urology Unit, Al-Amiri Hospital, Kuwait City, Kuwait.
: To develop and validate a scoring system to assess the need for emergency intervention (EI) in patients with uncomplicated acute renal colic (ARC) due to ureteric stones. : From May 2017 to April 2019, 382 adult patients presented to emergency department with ARC due to ureteral stones diagnosed by non-contrast computed tomography. Patients with solitary kidney, complications secondary to obstruction (intractable vomiting, fever or sepsis), bilateral ureteric stones, Stage ≥3 chronic kidney disease or those who underwent treatment of urolithiasis within the past 6 months were excluded.
View Article and Find Full Text PDFInhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation.
J Appl Physiol (1985)
February 2020
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, College of Medicine and Science, Rochester, Minnesota.
Signaling via the tropomyosin-related kinase receptor subtype B (TrkB) regulates neuromuscular transmission, and inhibition of TrkB kinase activity by 1NMPP1 in mice worsens neuromuscular transmission failure (NMTF). We hypothesized that acute inhibition of TrkB kinase activity will impair the ability of the diaphragm muscle to produce maximal transdiaphragmatic pressure (Pdi) without impacting the ability to generate forces associated with ventilation, consistent with the greater susceptibility to NMTF in motor units responsible for higher-force nonventilatory behaviors. Adult male and female mice were injected with 1NMPP1 ( = 8) or vehicle (DMSO; = 8) 1 h before Pdi measurements during eupneic breathing, hypoxia/hypercapnia (10% O/5% CO), tracheal occlusion, spontaneous deep breaths ("sighs") and during maximal activation elicited by bilateral phrenic nerve stimulation.
View Article and Find Full Text PDFDiaphragm muscle function following midcervical contusion injury in rats.
J Appl Physiol (1985)
January 2019
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Midcervical spinal cord contusion injury results in tissue damage, disruption of spinal pathways, and motor neuron loss. Unilateral C4 contusion results in loss of 40%-50% of phrenic motor neurons ipsilateral to the injury (~25% of the total phrenic motor neuron pool). Over time after unilateral C4 contusion injury, diaphragm muscle (DIAm) electromyogram activity increases both contralateral and ipsilateral to the side of injury in rats, suggesting compensation because of increased activation of the surviving motor neurons.
View Article and Find Full Text PDFImpact of aging on diaphragm muscle function in male and female Fischer 344 rats.
Physiol Rep
July 2018
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
The diaphragm muscle (DIAm) is the primary inspiratory muscle in mammals and is active during ventilatory behaviors, but it is also involved in higher-force behaviors such as those necessary for clearing the airway. Our laboratory has previously reported DIAm sarcopenia in rats and mice characterized by DIAm atrophy and a reduction in maximum specific force at 24 months of age. In Fischer 344 rats, these studies were limited to male animals, although in other studies, we noted a more rapid increase in body mass from 6 to 24 months of age in females (~140%) compared to males (~110%).
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