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Single-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFExploring the Impact of Osteopathic Manipulative Treatment on Chronic Migraine Relief: A Case Study.
Cureus
February 2025
Family Medicine/Osteopathic Neuromusculoskeletal Medicine (ONMM), Edward Via College of Osteopathic Medicine, Spartanburg, USA.
For years, migraines have been the subject of extensive research, as their symptoms significantly burden individuals' quality of life. Existing treatments primarily rely on pharmaceutical interventions targeting various symptoms associated with migraines. However, the varying efficacy and side effects of these medications have led to the consideration of alternative treatment modalities to improve patient outcomes and minimize adverse effects.
View Article and Find Full Text PDFNetwork meta-analysis comparing efficacy of different strategies on medication-overuse headache.
J Headache Pain
February 2025
Department of Neurology, University Hospital Birmingham, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, B15 2GW, UK.
Background: Medication-overuse headache (MOH) is the most common secondary headache disorder, resulting from or leading to the frequent use of acute headache medications. Despite the availability of various treatment strategies, the optimal approach remains uncertain.
Objective: This network meta-analysis (NMA) aimed to evaluate the comparative efficacy of different strategies for managing MOH, focusing on reducing monthly headache days.
RHOBTB2-related paroxysmal hemiparesis: From alternating hemiplegia to hemiplegic migraine.
Parkinsonism Relat Disord
February 2025
Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies, EpiCARE, Rome, Italy; University Hospitals KU Leuven, Belgium.
We report a young patient harboring a RHOBTB2 likely pathogenic variant with recurrent episodes of headache, dysautonomia and hemiplegia consistent with hemiplegic migraine. Such episodes were responsive to flunarizine prophylaxis. Ictal MRI showed contralateral hemispheric hypoperfusion.
View Article and Find Full Text PDFMagnesium and Migraine.
Nutrients
February 2025
Geriatric Unit, Department of Medicine, University of Palermo, 90127 Palermo, Italy.
Migraine is a widespread and intricate neurological condition that involves various factors and is marked by recurring headache episodes. Migraine is among the ten neurological conditions accounting for the greatest disability in the whole population, the leading cause of disability for children and adolescents aged 5-19 years, and the second cause of disability for adults aged 20-59 years. Magnesium deficiency is also a very common condition resulting from diverse reasons, including insufficient dietary consumption or increased loss through the gastrointestinal or renal system.
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