AI Article Synopsis
- Local anesthetics block nerve signals by preventing sodium ions from moving through nerve membranes, disrupting communication along nerves.
- This article covers the pharmacology (how these drugs work) and toxicology (potential side effects) of local anesthetics.
- It highlights recent research on ropivacaine, a newer local anesthetic similar to bupivacaine but with fewer harmful effects on the body.
Article Abstract
Local anesthetic drugs interrupt nerve transmission by inhibiting the passage of sodium ions (Na+) across neuronal membranes. Signal propagation and transmission along central and peripheral nerve pathways are impeded after the injection of these drugs near or on neuronal tissue. This article briefly reviews the basic pharmacology and toxicology of local anesthetic agents as well as recent studies of regional anesthesia performed with ropivacaine, a versatile new amide local anesthetic with a duration of action similar to bupivacaine, but with less systemic toxicity.
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