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Importance: The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a commonly used outcome in heart failure trials. While comparing means between treatment groups improves statistical power, mean treatment effects do not necessarily reflect the clinical benefit experienced by individual patients.
Objective: To evaluate the association between mean KCCQ treatment effects and the proportions of patients experiencing clinically important improvements across a range of clinical trials and heart failure etiologies.
Spin Bias Is Common in the Abstracts and Main Body of Systematic Reviews and Meta-analyses of Hip Arthroscopy in the Setting of Borderline Hip Dysplasia.
Arthrosc Sports Med Rehabil
October 2024
Department of Orthopedic Surgery, University of California San Francisco, 1500 Owens Street, San Francisco, California, U.S.A.
Purpose: To assess the quality and presence of spin bias in the abstracts of systematic reviews and meta-analyses that evaluated the outcomes of using hip arthroscopy for the treatment of hip pathology in the setting of borderline hip dysplasia.
Methods: PubMed and Embase were searched using the terms "borderline hip dysplasia" and "systematic review" or "meta-analysis." Forty-one initial studies were identified, and 12 met the inclusion criteria.
Validity of data extraction in acupuncture meta-analysis: a reproducibility study protocol.
BMJ Open
November 2024
Evidence-based Medicine Center, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Introduction: Systematic review and meta-analysis occupy the apex of the evidence pyramid, serving as the most comprehensive and reliable form of evidence-based assessment. Data extraction is a crucial juncture in meta-analysis, establishing the underpinnings for the outcomes and deductions drawn from systematic reviews (SRs). However, the frequency of data extraction errors in meta-analysis is quite significant.
View Article and Find Full Text PDFPervasive biases in proxy genome-wide association studies based on parental history of Alzheimer's disease.
Nat Genet
December 2024
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history. Here, we report major limitations in current GWAS-by-proxy (GWAX) practices due to uncorrected survival bias and nonrandom participation in parental illness surveys, which cause substantial discrepancies between AD GWAS and GWAX results. We demonstrate that the current AD GWAX provide highly misleading genetic correlations between AD risk and higher education, which subsequently affects a variety of genetic epidemiological applications involving AD and cognition.
View Article and Find Full Text PDFPrevalence and characteristics of lumbar ribs: a meta-analysis with anatomical and clinical considerations.
Surg Radiol Anat
December 2024
Department of Orthopedics and Rehabilitation, Jagiellonian University Medical College, Balzera 15, Zakopane, 34- 500, Poland.
Background: Lumbar ribs (LR) are a rare and relatively unknown anatomical abnormality of the lumbar spine. The literature provides better understanding regarding other spinal congenital variations like cervical ribs or lumbosacral transitional vertebrae, which are rather commonly recognised conditions. Thus, this meta-analysis aimed to provide data on prevalence and key characteristics of LR.
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