AI Article Synopsis
- The study examined T-helper cell responses to influenza A by analyzing T-cell receptor V beta gene diversity in specific Th lymphocytes.
- When T-lymphocytes from blood were stimulated with a particular peptide, they quickly became oligoclonal, primarily expanding T-cell receptor V beta 3 genes.
- To track changes in diversity over time during antigenic stimulation, specific probes were used to focus on hemagglutinin-specific T-lymphocyte clones.
Article Abstract
Human helper T-cell (Th) responses to influenza A virus were studied by analyzing T-cell receptor V beta gene diversity in hemagglutinin-specific Th lymphocytes. The T-lymphocyte population from peripheral blood became quickly oligoclonal when stimulated in vitro with the HA306-329 peptide, and T-cell receptor V beta 3 genes were mainly expanded. Moreover, specific junctional region oligonucleotide probes corresponding to hemagglutinin-specific clones were used to estimate temporal diversity during antigenic stimulations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC189751 | PMC |
| http://dx.doi.org/10.1128/JVI.69.12.8046-8050.1995 | DOI Listing |
Publication Analysis
Top Keywords
t-cell receptor
12
influenza virus
8
receptor beta
8
preferential usage
4
t-cell
4
usage t-cell
4
receptor influenza
4
virus hemagglutinin-specific
4
hemagglutinin-specific human
4
human cd4+
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!