AI Article Synopsis
- Echocardiography on 16 children undergoing bone marrow transplantation (BMT) for mucopolysaccharidoses revealed that 44% had cardiac issues pre-BMT.
- After one year post-BMT, some cardiac problems showed improvement: 2 out of 3 patients with left ventricular restriction and one with hypertrophy saw resolution.
- At a follow-up of 2.5 years, there was no worsening of existing cardiac issues or new developments in the remaining patients, indicating that BMT can lead to cardiac improvement in many affected children.
Article Abstract
Echocardiography was performed in 16 children undergoing bone marrow transplantation (BMT) for mucopolysaccharidoses. Cardiac involvement before BMT was detected in seven (44%). One year after BMT (11 patients/five with cardiac involvement), left ventricular restriction resolved in 2/3 patients and hypertrophy in one. In the remainder, at mean follow up of 2.5 years, no progression of preexisting or development of new cardiac involvement was noted. It is concluded that in a significant proportion of patients with mucopolysaccharidoses, cardiac involvement improved after BMT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511298 | PMC |
| http://dx.doi.org/10.1136/adc.73.3.259 | DOI Listing |
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