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Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma.
Proteomics
November 2004
Department of Pathology, Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
The histopathologic type of lung cancer is known to be correlated with tumor behavior and prognosis. However, this classification is subjective and no specific molecular markers have been identified. The aim of this study was to identify protein markers in different types of nonsmall cell lung cancers.
View Article and Find Full Text PDFGenetic variants showing apparent hot-spots in the human serum albumin gene.
Clin Chim Acta
November 1999
Department of Biochemistry, University of Pavia, I-27100, Pavia, Italy.
The molecular defects of three different slow-migrating genetic variants of human serum albumin, albumins Kamloops (formerly RIH), Stirling and Amsterdam, previously characterized only by electrophoretic and dye-binding studies, are now reported. Two of them are proalbumin variants: sequential analysis of the purified whole proteins has established the mutation responsible for albumin Kamloops as -1Arg-->Gln, and for albumin Stirling as -2Arg-->His. A Glu-->Lys substitution in position 570 of the mature albumin molecule was determined in albumin Amsterdam by sequential analysis of two abnormal tryptic fragments.
View Article and Find Full Text PDFClassification of an alloalbumin.
Ann Clin Biochem
July 1994
Institute of Biochemistry, Royal Infirmary, Glasgow, UK.
A technique for the separation of human alloalbumin variants by means of isoelectric focusing in the presence of 8M urea and 60 mM L-serine is described. The potential usefulness of this technique in the detection and classification of genetic heterogeneity at the albumin locus is demonstrated by the differentiation of three human alloalbumin variants of European origin.
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