Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801361 | PMC |
Publication Analysis
Top Keywords
Similar Publications
A Modified Method for DNA Extraction From Buccal Cells for Genetic Epidemiological Studies Among Children.
Cureus
December 2024
Department of Clinical Research, University of San Luis Potosí, San Luis Potosí, MEX.
Background: In large-scale molecular studies, a protocol that generates high yields and quality DNA for future polymerase chain reaction (PCR) assays is needed. The collection of buccal cells by cytobrush may represent an efficient, noninvasive, and inexpensive method for obtaining genetic material from school populations. The aim of this study was to develop a method to obtain genomic DNA from buccal cells of schoolchildren, and the DNA was extracted immediately after collecting the buccal cell samples and after storing the samples for 8 months at -20 °C to establish the feasibility of the method for epidemiological studies.
View Article and Find Full Text PDFBifunctional nanomaterial enabled high-specific isolation of urinary exosomes for cervical cancer metabolomics analysis and biomarker discovery.
Talanta
April 2025
Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University, Shanghai, 201203, China; Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, 201203, China. Electronic address:
Cervical cancer (CC) remains a critical public health issue, highlighting the importance of early detection. However, current methods such as cytological and HPV testing face challenges of invasiveness and low patient compliance. Exosomes, emerging as crucial in cancer diagnosis, offer promise due to their noninvasive, highly specificity, and abundant biomarkers.
View Article and Find Full Text PDFImmuno-PET Imaging of CD93 Expression with Cu-Radiolabeled NOTA-mCD93 ([Cu]Cu-NOTA-mCD93) and Insulin-Like Growth Factor Binding Protein 7 ([Cu]Cu-NOTA-IGFBP7).
Mol Pharm
December 2024
Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
CD93 is overexpressed in multiple solid tumor types, serving as a novel target for antiangiogenic therapy. The goal of this study was to develop a Cu-based positron emission tomography (PET) tracer for noninvasive imaging of CD93 expression. Antimouse-CD93 mAb (mCD93) and the CD93 ligand IGFBP7 were conjugated to a bifunctional chelator, -isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid (-SCN-NOTA) and labeled with Cu.
View Article and Find Full Text PDFLabel-Free Microfluidic Apheresis of Circulating Tumor Cell Clusters.
Adv Sci (Weinh)
October 2024
Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, 02129, USA.
Screening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which are known to be highly metastasis-competent, yet ultrarare.
View Article and Find Full Text PDFDiffuse Cystic Lung Disease: A Clinical Guide to Recognition and Management.
Chest
August 2024
Department of Respiratory Medicine, St. Vincent's University Hospital, Dublin, Ireland; School of Medicine, University College Dublin, Dublin, Ireland. Electronic address:
Topic Importance: Diffuse cystic lung diseases (DCLDs) represent a group of pathophysiologically heterogeneous entities that share a common radiologic phenotype of multiple thin-walled pulmonary cysts. DCLDs differ from the typical fibroinflammatory interstitial lung diseases in their epidemiology, clinical presentation, molecular pathogenesis, and therapeutic approaches, making them worthy of a distinct classification. The importance of timely and accurate identification of DCLDs is heightened by the impact on patient management including recent discoveries of targeted therapeutic approaches for some disorders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!