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IL-7 secreted by keratinocytes induces melanogenesis via c-kit/MAPK signaling pathway in Melan-a melanocytes.
Arch Dermatol Res
January 2025
Department of Genetics & Biotechnology, Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Youngin, 17104, Republic of Korea.
Abnormal melanin synthesis within melanocytes can result in pigmentary skin disorders. Although pigmentation alterations associated with inflammation are frequently observed, the precise reason for this clinical observation is still unknown. More specifically, although many cytokines are known to be critical for inflammatory skin processes, it is unclear how they affect epidermal melanocyte function.
View Article and Find Full Text PDFChanges in Serum Proteins in Cats with Obesity: A Proteomic Approach.
Animals (Basel)
January 2025
Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.
Obesity is defined as the excessive accumulation of adipose tissue and is currently the most common disease in cats. Similarly to humans, obesity negatively impacts the health and welfare of cats, predisposing them to many other disorders. The objective of this study was to compare the serum proteomes of normal-weight and overweight/obese cats, aiming to gain insights into the physiopathology of feline obesity and potentially identify new biomarkers.
View Article and Find Full Text PDFThe importance of Fcγ and C-type lectin receptors in host immune responses during pneumonia.
Infect Immun
December 2024
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, the Thoracic Diseases Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
pneumonia (PJP) remains a significant cause of morbidity and mortality during AIDS. In AIDS, the absence of CD4 immunity results in exuberant and often fatal PJP. In addition, organism clearance requires a balanced macrophage response since excessive inflammation promotes lung injury and respiratory failure.
View Article and Find Full Text PDFHeterozygous Beta-Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions.
Prenat Diagn
November 2024
Department of Obstetrics & Gynaecology, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Aim: In this article, we present two cases of severe fetal hemolytic anemia based on a beta-thalassaemia trait inherited from a single parent.
Results: These cases, presented at 20 and 28 weeks' gestation, necessitated intra-uterine blood transfusions. This occurrence is remarkable because it challenges the common assumption that beta-thalassaemia typically has no prenatal implications regarding fetal anemia.
Nonclinical evaluations of deucravacitinib and Janus kinase inhibitors in homeostatic and inflammatory pathways.
Front Immunol
October 2024
Translational Medicine, Immunology, Cardiovascular & Neuroscience Disease Team, Bristol Myers Squibb, Princeton, NJ, United States.
Article Synopsis
- Translational medicine aids in discovering new drugs and predicting side effects by examining the selectivity of drugs that target specific pathways like the JAK-STAT signaling pathway.
- Deucravacitinib is highlighted as a first-in-class drug that selectively inhibits TYK2, unlike traditional JAK inhibitors that target multiple JAK family members, potentially leading to broader side effects.
- Clinical trials indicate that deucravacitinib has a different safety profile from JAK1,2,3 inhibitors, as it does not suppress certain blood cell production processes (thrombopoiesis, erythropoiesis, and myelopoiesis) that the JAK inhibitors affect.
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