A genetic study of psychiatric diseases meets a lot of difficulties because of incomplete penetrance, phenocopies, probable genetic heterogeneity. The progress in exploring of new effective markers and human genome mapping enables one to undertaken a systematic search for alleles confirming susceptibility to manic depressive illness and schizophrenia. It is important therefore to have in one's disposal the collection of DNA samples appropriate for different aspects of molecular genetic study. The collection of DNA samples deposited in National Centre for Mental Health of Russian Academy of Medical Sciences includes DNA of informative small-scaled families and a number of DNA from unrelated subjects with manic-depressive illness, schizophrenia, schizoaffective disorders. This collection may be used for linkage analysis, association and sib-pair studies and for detection of mutations responsible for mental diseases.
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