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Glow in the dark tumor: Enhanced near-IR visualization and destruction of cancer with a self-quenched theranostic.
Eur J Pharm Biopharm
January 2025
Late diagnosis is one of the major obstacles for the treatment of breast cancer which can be overcome with a system offering sensitive imaging and selective therapeutic effect. In this study, we developed a "dark-bright" multifunctional drug delivery system bringing real-time imaging and non-invasive therapy together. Theranostic ability of the system was delivered by Verteporfin (VP), serving as a fluorescence probe and a photosensitizer.
View Article and Find Full Text PDFAnalysis of the biomolecular profile by Fourier transform vibrational spectroscopy (FT-IR) in Acinetobacter baumannii after application of photodynamic therapy with curcumin "in vitro ".
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Photobiology Applied to Health (PhotoBioS) - Research and Development Institute- R&DI, University of Vale do Paraíba, Univap. Shishima Hifumi Avenue, 2911, 12244-000, São José dos Campos, São Paulo, Brazil. Electronic address:
Acinetobacter baumannii stands out for its antimicrobial resistance and high capacity to cause hospital infections, posing a severe threat to global public health. Thus, there is an urgent need for new therapeutic strategies. This work applied photodynamic therapy (PDT) with curcumin to Acinetobacter baumannii, and bacterial cell viability was assessed.
View Article and Find Full Text PDFPhotosensitizable ZIF-8 BioMOF for Stimuli-Responsive Antimicrobial Phototherapy.
Mol Pharm
January 2025
Department of Nanomaterials and Application Technology, Center of Innovative and Applied Bioprocessing (CIAB), Department of Biotechnology (DBT), Government of India, Sector 81 (Knowledge City), S.A.S. Nagar, Mohali 140306, Punjab, India.
Resistant pathogens are increasingly posing a heightened risk to healthcare systems, leading to a growing concern due to the lack of effective antimicrobial treatments. This has prompted the adoption of antimicrobial photodynamic therapy (aPDT), which eradicates microorganisms by generating reactive oxygen species (ROS) through the utilization of a photosensitizer, photons, and molecular oxygen. However, a challenge arises from the inherent characteristics of photosensitizers, including photobleaching, aggregation, and self-quenching.
View Article and Find Full Text PDFComparative Efficacy of Ultrasonic Scalpel Surgery With Photodynamic Therapy Versus Trichloroacetic Acid Application in Treating HPV-Related Condyloma Acuminata: A Randomized Clinical Trial.
J Med Virol
January 2025
Sao Carlos Institute of Physics, University of Sao Paulo, Sao Paulo, Brazil.
Human papillomavirus (HPV) infections rank as the most prevalent sexually transmitted infections globally. The Brazilian Ministry of Health recommends the topical use of 70%-90% trichloroacetic acid (TAA) for treating condyloma acuminata, yet this method suffers from a high recurrence rate of 36% and requires roughly six applications. Topical photodynamic therapy (PDT) has shown effectiveness in targeting subclinical lesions, but it also necessitates multiple sessions for complete lesion clearance.
View Article and Find Full Text PDFApplications of polymeric nanoparticles in drug delivery for glioblastoma.
Front Pharmacol
January 2025
Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, China.
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, and adaptability to the tumor microenvironment (TME). This review explores the diverse applications of polymeric nanoparticles (NPs) in GBM treatment, including delivery of chemotherapeutics, targeted therapeutics, immunotherapeutics, and other agents for radiosensitization and photodynamic therapy.
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