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Resveratrol polysaccharide is less cytotoxicity and inhibits UVA-, UVB-, and tertiary-butyl hydroperoxide-induced injury in human keratinocytes.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Meisterbio Co., Ltd., Okayama, Japan.
Natural stilbene compounds, such as resveratrol and pterostilbene, have been focused on owing to their diverse biological activities associated with antioxidant, anti-inflammatory, and anti-aging properties. However, their low water solubility limits their advanced applications. In this study, we investigated the protective effects of selected stilbene compounds (resveratrol, oxyresveratrol, gnetol, piceatannol, and pterostilbene) and their water-soluble derivatives (piceid, resveratrol polysaccharide, pterostilbene trisaccharide, and pterostilbene polysaccharide) against UVA-, UVB irradiation, tertiary-butyl hydroperoxide (t-BuOOH)- and hydrogen peroxide (HO)-induced injury in human epidermal cells.
View Article and Find Full Text PDFDifferential modulation of the hepatocellular metabolome, cytoprotective and inflammatory responses due to endotoxemia and lipotoxicity.
Mol Omics
January 2025
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.
The present work aimed to examine the primary mechanisms of liver damage, namely the impact of gut-derived endotoxins along the gut-liver axis and adipose-derived free fatty acids along the adipose-liver axis. These processes are known to play a significant role in the development of hepatic inflammation and steatosis. Although possible overlapping in the pathogenesis was expected, these processes have unique pathophysiological consequences.
View Article and Find Full Text PDFDose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation.
Dis Model Mech
January 2025
Institute of Molecular Health Sciences, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland.
Article Synopsis
- Atopic dermatitis (AD) is a chronic skin condition with a weakened epidermal barrier and altered immune responses, linked to reduced NRF2 activity in affected patients.
- Genetic and proteomics studies using special mouse models showed that low NRF2 levels lead to increased DNA damage and more senescent skin cells.
- While temporarily activating NRF2 may offer some protection, excessive or long-term activation can worsen skin issues, highlighting the need for careful management in treating AD patients.
Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone.
Ecotoxicol Environ Saf
December 2024
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 31, Messina 98166, Italy; Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy. Electronic address:
Benzisothiazolinone (BIT) is a preservative and antimicrobial agent widely used in various household and industrial products. It is readily detectable in pesticides, polishes, printing inks and detergents. This extensive use is reflected in a vast amount of this compound in the environment, which may cause toxic effects in organisms that come in contact with it.
View Article and Find Full Text PDFDehydroevodiamine Alleviates Doxorubicin-Induced Cardiomyocyte Injury by Regulating Neuregulin-1/ErbB Signaling.
Cardiovasc Ther
January 2025
Department of Cardiothoracic Surgery, Ningbo Medical Center Lihuili Hospital of Ningbo University, No. 57, Xingning Rd, Ningbo City 315041, Zhejiang Province, China.
Doxorubicin (DOX) is a widely used antitumor drug; however, its use is limited by the risk of serious cardiotoxicity. Dehydroevodiamine (DHE) is a quinazoline alkaloid which has antiarrhythmic effects. The aim of this study was to investigate the protective effect of DHE on doxorubicin-induced cardiotoxicity (DIC) and its potential mechanism.
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