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Efficacy of Therapeutic Apheresis for Cryoglobulinemic Vasculitis Patients with Renal Involvement: A Systematic Review.
Blood Purif
January 2024
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Introduction: Therapeutic apheresis (TA) is commonly used for cryoglobulinemic vasculitis (CV) patients, but its efficacy remains uncertain. This systematic review aimed to assess the efficacy of different TA modalities, such as plasma exchange (PE), plasmapheresis (PP), and cryofiltration (CF), in treating CV patients with renal involvement.
Methods: Literature search of MEDLINE, EMBASE, and Cochrane Databases was conducted up to December 2022.
Good response to cryofiltration in a patient with cryoglobulinemic vasculitis complicated with systemic lupus erythematosus.
Ther Apher Dial
April 2021
Department of Immuno-Rheumatology Center, Arisawa General Hospital, Osaka, Japan.
Effectiveness of cryofiltration and mizoribine combination with oral steroid therapy in a patient with membranoproliferative glomerulonephritis due to essential cryoglobulinemia.
CEN Case Rep
August 2019
Division of Nephrology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka, 830-0011, Japan.
Article Synopsis
- A 65-year-old male with nephrotic syndrome was hospitalized due to severe edema and skin issues, revealing impaired kidney function and cryoglobulinemia.
- He received treatment that included corticosteroids and immunosuppressants, but initially struggled with steroid resistance, necessitating cryofiltration.
- After treatment adjustments, the patient achieved complete remission and maintained it without symptoms for three years.
Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases.
Ther Apher Dial
June 2017
Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine, Osaka, Japan.
Cryoglobulinemia can induce systemic vasculitis affecting various organs such as skin, peripheral nerves, and kidney. The disease can induce chronic organ failure and even be life-threatening. Cryofiltration has been applied for the treatment of cryoglobulinemic vasculitis.
View Article and Find Full Text PDFOptimum Conditions for the Efficacy and Safety of Cryofiltration Apheresis: An Analysis of Circuit Temperatures Depending on Plasma Flow Rate and Cooling Coil Lengths/Turns.
Ther Apher Dial
August 2015
Department of Clinical Engineering, Itabashi Chuo Medical Center, Itabashi, Japan.
A system providing both appropriate cooling and warming are needed for the efficacy and safety of cryofiltration (CF) plasmapheresis. We measured some points of CF circuit temperatures with varying plasma flow rates (QP = 10-40 mL/min) and the numbers of connecting cooling coils (one or two) under the conditions of blood flow rate (QB ) 100 mL/min with 7700-mm coil length, 19 turns, and 50-mL priming volume. We measured the respective temperatures of each point of starting/returning for an extracorporeal circuit (TA /TV ), intracooling coil (TC ), and post-plasma fractionator (PF) (TPF ).
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