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Synergism of Specific Maca Phenotypes () in Combination with Saw Palmetto () Extract for Chemoprevention of Prostate Cancer as Determined in In Vitro Cytotoxicity Assays on Human Epithelial and Prostate Cancer Cells.
Molecules
November 2024
NICM Health Research Institute, Western Sydney University, 158-160 Hawkesbury Road, Sydney, NSW 2145, Australia.
Selected phenotypes of dried maca () hypocotyls and supercritical CO extract (USPlus) of saw palmetto () were used to determine their targeted, cytotoxic action in prostate cancer cells. Fingerprinting by HPLC-MS and PCA analysis showed compositional differences in glucosinolates, amides, macamides, and other alkaloids, which varied based on the color and the size of hypocotyls. These phytochemical differences translated into a higher antioxidant potential of red maca than black maca samples.
View Article and Find Full Text PDFMeasuring the efficacy of Serenoa repens (USPlus) extract with mobile uroflowmetry.
Can J Urol
December 2024
Department of Urology, Northwell Health, Manhasset, New York, USA.
Introduction: Benign prostatic hyperplasia (BPH) is a prevalent condition affecting a significant portion of the male population, leading to secondary lower urinary tract symptoms (LUTS). Alternative therapies such as phytotherapy using Lipidosterolic extract of Serenoa repens (LSESR USPlus) are commonly used. However, the efficacy of LSESr remains controversial due to conflicting data.
View Article and Find Full Text PDFMulti-pharmacological treatment for young subfertile males with chronic prostatitis/chronic pelvic pain syndrome.
Investig Clin Urol
November 2024
Department of Urology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Purpose: This study evaluated the effectiveness of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) treatments using multiple pharmaceutical agents that could simultaneously preserve or enhance fertility capability.
Materials And Methods: This was a single-center-based, randomized controlled study, whereas the final analysis evaluated a total 350 CP/CPPS patients (age range, 28-40 years) and 50 patients were randomly allocated to each therapeutic group, with a 1:1 ratio. The therapeutic groups consist of tadalafil (group 1, 5 mg daily), L-carnitine (group 2, 2 g daily), extract (group 3, 320 mg daily), group 4 (tadalafil+L-carnitine), group 5 (tadalafil+), group 6 (L-carnitine+), and group 7 (tadalafil+L-carnitine+).
Beneficial effects of saw palmetto () fruit extract on the urinary symptoms of healthy Japanese adults with possible lower urinary tract symptoms: A randomized, double-blind, placebo-controlled study.
Nutr Health
July 2024
Medical Corporation Seishinkai, Takara Clinic, Shinagawa-ku, Tokyo, Japan.
Saw palmetto extract (SPE) is the most commonly used supplement for the treatment of lower urinary tract symptoms (LUTS), but most evidence is for those with LUTS, and little data is verifying its effectiveness for those who do not have the disease but are troubled by symptoms. The purpose of this study was to examine the effect of SPE on the improvement of urinary frequency problems that present stress due to urinary urgency in daily life, among healthy Japanese adults aged ≥50 years who are not diagnosed with benign prostatic hyperplasia or overactive bladder. They were randomly assigned to the SPE group or placebo group (34 participants per group) using a computerized random number generator.
View Article and Find Full Text PDFSaw Palmetto for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia.
Am Fam Physician
May 2024
Naval Hospital Camp Pendleton, Camp Pendleton, California.
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