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Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.
J Clin Med
December 2024
Department of Rheumatology, Päijät-Häme Central Hospital, Wellbeing Services County of Päijät-Häme, 15850 Lahti, Finland.
Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate crystals in the joints due to elevated serum uric acid levels. Its prevalence and associated healthcare burden have been rising in recent decades, a trend expected to continue. It is crucial to recognize that gout and hyperuricemia are not merely causes of painful joint flares, but systemic metabolic disorders linked to a broad spectrum of comorbidities such as cardiovascular diseases, chronic kidney disease, diabetes, insulin resistance, steatotic liver disease, osteoarthritis, and respiratory and eye diseases.
View Article and Find Full Text PDFNetwork pharmacology and transcriptomics explore the therapeutic effects of Ermiao Wan categorized formulas for diabetes in mice.
Sci Rep
November 2024
Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, China Pharmaceutical University, 639 Longmian road, Nanjing, China.
Ermiao wan (EMW) is a classical traditional Chinese medicine formula, with two modified versions including Sanmiao wan (SMW) and Simiao wan (FMW). These Ermiao wan categorized formulas (ECFs) are traditionally used to treat gouty arthritis and hyperuricemia. However, their potential benefits and mechanisms on diabetes remain to be explored.
View Article and Find Full Text PDFExploration of the potential mechanism of Yiyi Tongfeng Formula in the treatment of acute gouty arthritis based on network pharmacology and molecular docking: A review.
Medicine (Baltimore)
September 2024
Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
The global prevalence of gout is on the rise. Yiyi Tongfeng Formula (YTF), a traditional herbal compound, has gained recognition for its efficacy in managing acute gouty arthritis (AGA). Despite its widespread use, the underlying mechanisms of YTF in AGA treatment remain largely undefined.
View Article and Find Full Text PDFSynthesis and Biological Evaluation of Novel Chlorogenic Acid-Apigenin Conjugates as Anti-acute Gout Agents.
Chem Pharm Bull (Tokyo)
August 2024
Institute of Applied Chemistry, Jiangxi Academy of Sciences.
Gout is the second largest metabolic disease worldwide after diabetes, with acute gouty arthritis as most common symptom. Xanthine oxidase (XOD) and the NOD like receptor-3 (NLRP3) inflammasome are the key targets for acute gout treatment. Chlorogenic acid has been reported with a good anti-inflammatory activity, and Apigenin showed an excellent potential in XOD inhibition.
View Article and Find Full Text PDFKnowledge, Attitudes, and Practices about Hyperuricemia and Gout in Community Health Workers and Patients with Diabetes.
Healthcare (Basel)
May 2024
Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Article Synopsis
- - The study investigated the knowledge and attitudes about hyperuricemia and gout among community health workers and diabetic patients in Chenghua District, Chengdu, between August 2021 and January 2022, using two questionnaires.
- - Results indicated that community health workers had a moderate level of knowledge (average score of 17.74/30) while about half of general practitioners were unaware of key facts, such as target serum uric acid levels and treatment for gout.
- - Among diabetic patients, only 32.3% were aware of hyperuricemia and 60.8% about gout, with many misconceptions, including the belief that hyperuricemia always leads to gout (87.8%) and that
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