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Inter-nesting area use, migratory routes, and foraging grounds for hawksbill turtles (Eretmochelys imbricata) in the Western Caribbean.
PLoS One
March 2025
Department of Biology, Purdue University Fort Wayne, Fort Wayne, Indiana, United States of America.
The hawksbill turtle, Eretmochelys imbricata, has been at risk of extinction for more than 40 years and remains critically endangered. While nesting beach protection is important for hatchling production, identifying inter-nesting, migratory, and foraging habitats is crucial for mitigating threats to population recovery. We report the use of satellite telemetry to monitor movements of 15 hawksbill turtles in the Western Caribbean.
View Article and Find Full Text PDFDirect Cytosolic Delivery of siRNA Conjugates: A Paradigm in Antiangiogenic Therapy for Choroidal Neovascularization.
ACS Nano
March 2025
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Small interfering RNA (siRNA) has garnered tremendous interest as a potential therapeutic tool because of its intriguing gene-silencing ability. Toward the success in the manufacture of siRNA therapeutics for the potential treatment of choroidal neovascularization (CNV), siRNA conjugated with dual functional units of membrane-penetrating heptafluoropropyl and age-related macular degeneration-targeting cyclic Arg-Gly-Asp (RGD) peptide was attempted for transcellular transportation into the cell interiors. Of note, cyclic RGD allowed selective affinities toward the angiogenic endothelial cells in the pathological CNV.
View Article and Find Full Text PDFHost cytoskeleton and membrane network remodeling in the regulation of viral replication.
Biophys Rep
February 2025
Unit of Cell Biology and Imaging Study of Pathogen Host Interaction, The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.
Viral epidemics pose major threats to global health and economies. A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures, known as viral factories, which support viral genome replication. Viral infection in many cases induces the cytoskeletal network to form cage-like structures around viral factories, including actin rings, microtubule cages, and intermediate filament cages.
View Article and Find Full Text PDFHospital cybersecurity: Emergency planning response and preparedness to mitigate the effects of a potential cyberattack on French hospitals in Paris, France.
J Emerg Manag
March 2025
Direction des Services Numériques, Département Sécurité du Système d'Information, Campus Picpus, Paris, France.
Over the last few years, numerous hospitals in France have been subject to increasingly frequent and severe cyberattacks that have disrupted healthcare provision to varying degrees. To mitigate this threat, especially in light of the forthcoming 2024 Olympic Games, Assistance Publique-Hôpitaux de Paris in Paris has been developing contingency plans that have been tested in simulated exercises called CRYPTolocker EXercice since May 2021. The latest simulated ransomware cyberattack that involved more than 200 participants took place on July 5, 2023, and lasted for 24 hours.
View Article and Find Full Text PDFComplex relationship between soil fungi and conservation value assessments in boreal forests.
Conserv Biol
March 2025
Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Large-scale industrial forestry is a threat to biodiversity and imposes long-lasting changes to many forested biomes. Preserving forests as reserves is an important component of the strategy for safeguarding forest biodiversity. Yet, the selection of forests of high biodiversity value is usually based on proxies (i.
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