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Role of Interleukins-8, -17 and -22 in Iraqi postmenopausal women with Osteoporosis.
Cytokine
January 2025
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address:
Objectives: Osteoporosis (OP) is a systemic skeletal disease characterized by low bone mineral density and deterioration of bone architecture, resulting in bone strength reduction and increased fracture susceptibility. Estrogen deficiency in post-menopausal women is possibly responsible for the instability between bone formation and resorption, which is managed by specific osteoclastogenic cytokines that may be leading to resorption. This study aims to estimation of the concentrations of interleukins -8, -17, -22, beside to certain parameters in blood serum and explained their roles in the development of osteoporosis pathogenicity in postmenopausal women.
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- Anemia is highly common in rheumatoid arthritis (RA) patients, with 54.55% of the 330 studied individuals showing anemia, reflecting the impact of disease severity and inflammation on hemoglobin levels.
- The study revealed that anemic RA patients had a higher Disease Activity Score (DAS28) and significantly elevated inflammatory markers (C-reactive protein and erythrocyte sedimentation rate) compared to non-anemic patients.
- There were significant links identified between anemia, longer disease duration, greater RA severity, and increased levels of inflammation, indicating that managing inflammation could be crucial for addressing anemia in RA patients.
Acute Febrile Illness in India: An Epidemiological Retrospective Study.
Infect Disord Drug Targets
October 2024
School of Biomedical Science, Galgotias University, Greater Noida, India.
Article Synopsis
- Acute Febrile Illness (AFI) is common in India and involves a range of causes, necessitating a study of the clinical parameters in North Indian patients to better understand its complexities.
- A total of 1,819 patients were examined from 2017 to 2021, with 211 selected for detailed analysis based on samples collected during clinical evaluations, including blood and urine.
- Key biochemical (like CRP and SGPT) and hematological parameters (like total leukocyte count) were analyzed, revealing significant variability and trends over the years, while also correlating with factors like patient temperature at admission and hospital stay duration.
Cilgavimab and tixagevimab as pre-exposure prophylaxis in vaccine non-responder kidney transplant recipients during a period of prevalent SARS-CoV-2 BA.2 and BA.4/5 variants-a prospective cohort study (RESCUE-TX).
EBioMedicine
November 2024
Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:
Background: The response to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination is severely impaired in patients on maintenance immunosuppression after kidney transplantation.
Methods: We conducted a prospective cohort study of 194 kidney transplant recipients (KTR) who exhibited no response to SARS-CoV-2 vaccinations (i.e.
ESR Essentials: imaging of suspected child abuse-practice recommendations by the European Society of Paediatric Radiology.
Eur Radiol
September 2024
Division of Clinical Medicine, University of Sheffield, Sheffield, UK.
The goal of this paper is to provide a useful desktop reference for the imaging of suspected child abuse with clear, age-specific pathways for appropriate evidence-based imaging and follow-up. We aim to provide a road map for the imaging evaluation and follow-up of this important and vulnerable cohort of patients presenting with signs and symptoms concerning for inflicted injury. As the imaging recommendations differ for children of different ages, we provide a flowchart of the appropriate imaging pathway for infants, toddlers, and older children, which allows ease of selection of which children should undergo skeletal survey, non-contrast computed tomography (CT) brain with 3-dimensional (D) reformats, and magnetic resonance imaging (MRI) of the brain and whole spine.
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