Magnitude estimations involving spatial characteristics, such as distance, typically show a compressive function when estimates are made from memory. In particular, as the magnitude of a property grows larger and larger, estimates become more and more inaccurate, with increasing underestimates of the actual magnitude. Previous theories have attempted to explain this difference by supposing that magnitude estimation was accomplished through a reperceptual process, in which the errors of perception are magnified, or a transformation process, in which the memory trace undergoes a consistent alteration toward a more schematic form. The present experiments present evidence in support of an uncertainty hypothesis. When subjects are uncertain of the actual value of a distance, they are forced to guess on the basis of the mean distance they encountered, because they are unable to retrieve the information accurately. When they can retrieve the information, they are more certain and their estimates are more accurate. This hypothesis was also extended to integrative conditions in which the subjects were presented with the stimulus display in a piecemeal fashion. In these cases, distance estimates were derived by combining spatial representations. This method of presentation caused distance estimates to become less accurate.
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http://dx.doi.org/10.3758/bf03197261 | DOI Listing |
Brain
January 2025
Translational Neuroimaging Laboratory, Montreal Neurological Institute, H3A 2B4, Montreal, Canada.
Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment.
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
School of Molecular and Life Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA 6845, Australia.
Natural aging is associated with mild memory loss and cognitive decline, and age is the greatest risk factor for neurodegenerative diseases, such as Alzheimer's disease. There is substantial evidence that oxidative stress is a major contributor to both natural aging and neurodegenerative disease, and coincidently, levels of redox active metals such as Fe and Cu are known to be elevated later in life. Recently, a pronounced age-related increase in Cu content has been reported to occur in mice and rats around a vital regulatory brain region, the subventricular zone of lateral ventricles.
View Article and Find Full Text PDFFront Immunol
January 2025
Translational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy.
Background: Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to (Mtb) in patients with TBI and TB disease.
Methods: We enrolled TBI and TB patients with and without IMID.
Arch Gerontol Geriatr
January 2025
School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada. Electronic address:
Purpose: Although several studies have reported positive associations between functional social support (FSS) and memory, few have explored how other social variables, such as marital status, may affect the magnitude and direction of this association. We examined whether marital status modifies the association between FSS and memory in a sample of community-dwelling, middle-aged and older adults.
Methods: Data at three timepoints, spanning six years, were analyzed from the Tracking Cohort of the Canadian Longitudinal Study on Aging (n = 10,318).
Alzheimers Dement
January 2025
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Introduction: We compared the relationship between offspring education and cognitive health outcomes among Hispanic and White adults.
Methods: We used data from Hispanic and White (1998-2018) United States (US) Health and Retirement Study (HRS) participants (n = 17,484). We assessed cognitive function and decline using episodic memory scores in linear mixed models and incident cognitive impairment with no dementia (CIND) or probable dementia using the Langa-Weir 27-point-scale in Cox proportional hazards models.
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