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Toxicological Impact of Chronic Chlorpyrifos Exposure: DNA Damage and Epigenetic Alterations Induces Neoplastic Transformation of Liver Cells.
Biochem Biophys Res Commun
January 2025
Translational Genomics and Proteomics Laboratory, Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore, 641046, India. Electronic address:
Organophosphate pesticides (OPPs) are widely used chemical pesticides in all the developed countries. Among the OPPs, Chlorpyrifos (CPF) is predominantly used and has been linked to various adverse health effects from acute to chronic exposure. Exposure to pesticides both occupationally and environmentally causes frequent human health problems including neurological disorders, liver, kidney dysfunctions and cancer.
View Article and Find Full Text PDFAccidental Organophosphate Poisoning in a Patient Due to a Bed Bug Pesticide in the United Kingdom: A Case Report.
Cureus
December 2024
Emergency Medicine, North West Regional Hospital, Burnie, AUS.
Organophosphate (OP) compounds, developed during World War II, are a group of chemicals used as pesticides, insecticides and herbicides. As irreversible inhibitors of the enzyme acetylcholinesterase (AChE), they reduce anti-cholinesterase activity and therefore increase acetylcholine (ACh) levels at the neuromuscular junction (NMJ). Diazinon, the OP leading to the patient's symptoms in this report, is an amber-brown liquid that was once the most widely used insecticide in the United States of America.
View Article and Find Full Text PDFAssessing hepatotoxicity induced by co-exposure to chlorpyrifos and deltamethrin in hook snout carp (Opsariichthys bidens Günther): A comprehensive analysis biochemical and molecular response analysis.
Chemosphere
December 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China. Electronic address:
Article Synopsis
- Chlorpyrifos (CLP) and deltamethrin (DTM) are widely used insecticides that, when present together in water, pose significant risks to fish health and aquaculture sustainability.
- A study on hook snout carp (O. bidens) showed that exposure to both chemicals for 30 days resulted in increased toxicity and oxidative stress, indicated by altered enzyme activities and immune-related gene expression.
- The findings reveal that the combined exposure disrupts liver function, influences apoptotic regulation, and affects the overall health of fish, highlighting the ecological risks of using these pesticides together in aquatic environments.
Novel organophosphate esters and their transformation products in offshore sediment from Eastern China: Occurrence, temporal trend, and risk assessment.
Environ Int
December 2024
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
Offshore sediment serves as an important sink for traditional organophosphate esters (TOPEs) originating from terrestrial sources. However, the contamination characteristics of novel OPEs (NOPEs) and their hydrolyzed and hydroxylated transformation products (Di- and OH-OPEs) in marine sediment are still unknown. In this study, 34 OPE-associated contaminants were measured in six offshore sediment cores (71 samples) collected from Eastern China.
View Article and Find Full Text PDFPrecipitate, preterm labor in acute organophosphate poisoning in pregnancy: a case report.
Ann Med Surg (Lond)
December 2024
Institute Of Medicine, Maharajgunj, Nepal.
Introduction: Acute organophosphorus poisoning (AOPP) during pregnancy is uncommon. When complicated by preterm labor, it presents therapeutic dilemmas due to the lack of established guidelines.
Case Presentation: The authors describe a case of a 19-year-old primigravida at 33 weeks of gestation with AOPP.
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