21 patients on programmed hemodialysis for chronic renal insufficiency underwent hemodiafiltration (HDF) using dialyzers with highly-penetrable membrane made of polysulfone (Hemoflow F-40 and Hemoflow F-60). HDF has improved the patients' condition, eradicated skin itch, reduced polyneuropathy. Compared to standard hemodialysis, blood levels of creatinine and urea dropped by 6.9 and 3.7% more significantly. beta 2-microglobulin in the blood went down by 25.4 and 42.4%. The technique is provided of the removed filtrate replacement at the expense of the dialyzing liquid. The technique warrants a 60% decrease per session in blood beta 2-microglobulin.

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