Three battery tests, employing 444 Arbor Acres chickens, were conducted to study the anticryptosporidial efficacy of the polyether ionophorous anticoccidials alone and in combination with a new dihydroquinoline antioxidant, duokvin. The following efficacy percentages for the ionophores at the recommended level were established on the basis of oocyst output: lasalocid 45, monensin 37, semduramicin 29, narasin 23, and maduramicin and salinomycin 21. The efficacy of the ionophores, with the exception of lasalocid, could be increased to 36-88% by combination with duokvin. However, these combinations resulted in a significant weight gain reduction due to toxic interaction. Efficacy showed a strong negative correlation with body weight gain and bursa weight, suggesting an indirect mode of action against the parasite. It has been concluded that neither ionophorous anticoccidials nor their combinations with duokvin can be recommended for chemoprophylaxis against avian cryptosporidiosis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The highly hazardous veterinary drug "maduramicin" and its toxicokinetics in rats.
Heliyon
October 2024
State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing 400038, China.
Background: Maduramicin (MAD) is an anticoccidial veterinary drug, but it frequently causes fatal poisonings in poultry, livestock, or humans. However, there is no specific antidote or guidance on first aid for MAD poisoning.
Aim: The aim of the present study is to evaluate the acute toxicity and toxicokinetics of MAD after oral exposure, so as to make a foundation for developing diagnostic and therapeutic protocols for human intoxication.
Use of Metallic Nanoparticles Against Eimeria-the Coccidiosis-Causing Agents: A Comprehensive Review.
Biol Trace Elem Res
October 2024
Department of Parasitology, University of Agriculture, Faisalabad, 38040, Pakistan.
Coccidiosis is a protozoan disease caused by Eimeria species and is a major threat to the poultry industry. Different anti-coccidial drugs (diclazuril, amprolium, halofuginone, ionophores, sulphaquinoxaline, clopidol, and ethopabate) and vaccines have been used for their control. Still, due to the development of resistance, their efficacy has been limited.
View Article and Find Full Text PDFEfficacy and Growth Performance between Two Different Ionophore Coccidiostats (Narasin and Salinomycin) in Broiler Chickens after Challenge with spp.
Animals (Basel)
September 2024
Department of Poultry Science and Apiculture, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland.
The objective of this study was primarily to assess the different performance impacts of two ionophore coccidiostats (narasin and salinomycin) used to manage coccidiosis. While both products may be efficacious in controlling disease challenges, previous literature has suggested that some ionophores are less well tolerated by the broiler chickens. In this study, we were particularly interested to know how the use of different coccidiostat programs translates into broiler health and performance, as measured by zootechnical parameters such as the feed conversion ratio, average daily gain, and final body weight.
View Article and Find Full Text PDFRemoval of the Highly Toxic Anticoccidial Monensin Using Six Different Low-Cost Bio-Adsorbents.
Toxics
August 2024
Department of Soil Science and Agricultural Chemistry, Engineering Polytechnic School, University of Santiago de Compostela, 27002 Lugo, Spain.
The anticoccidial monensin (MON) is a high-concern emerging pollutant. This research focused on six low-cost bio-adsorbents (alfa, cactus, and palm fibers, and acacia, eucalyptus, and zean oak barks), assessing their potential for MON removal. Batch adsorption/desorption tests were carried out, and the results were fitted to the Freundlich, Langmuir, Linear, Sips, and Temkin models.
View Article and Find Full Text PDFNatural and modified clays as low-cost and ecofriendly materials to remove salinomycin from environmental compartments.
J Environ Manage
September 2024
Department Soil Science and Agricultural Chemistry, Engineering Polytechnic School, University of Santiago de Compostela, 27002, Lugo, Spain.
Antibiotics in the environment represent a substantial pollution threat. Among these emerging pollutants, ionophore anticoccidials are of special concern due to their potential ecological impact, persistence in the environment, and role in promoting antimicrobial resistance. To investigate the adsorption/desorption of the ionophore antibiotic salinomycin (SAL) on/from raw and modified clay adsorbents, batch-type experiments were performed using 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!