Effects of clonidine and apomorphine on motor and exploratory activity in mice with frontal lobe lesions.

The reported investigations were carried out on male Porton white mice, which had bilateral lesions of the cortex of frontal lobes made one month before the experiment. In mice with these lesions the excitatory effect of apomorphine (2 mg/kg) and clonidine (0.1 microgram/kg) was abolished, similarly as the inhibitory effect of clonidine (1 mg/kg) on the motor activity. The data indicate that noadrenergic neurons in the frontal lobes participate in the regulation of the motor and exploratory activity in mice.