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Cordycepin-Loaded Dental Pulp Stem Cell-Derived Exosomes Promote Aged Bone Repair by Rejuvenating Senescent Mesenchymal Stem Cells and Endothelial Cells.
Adv Healthc Mater
January 2025
Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Aging impairs bone marrow mesenchymal stem cell (BMSC) functions as well as associated angiogenesis which is critical for bone regeneration and repair. Hence, repairing bone defects in elderly patients poses a formidable challenge in regenerative medicine. Here, the engineered dental pulp stem cell-derived exosomes loaded with the natural derivative of adenosine Cordycepin (CY@D-exos) are fabricated by means of the intermittent ultrasonic shock, which dually rejuvenates both senescent BMSCs and endothelial cells and significantly improve bone regeneration and repair in aged animals.
View Article and Find Full Text PDFEffects of mono- and dual-frequency ultrasounds on structure and physicochemical properties of faba bean proteins.
Ultrason Sonochem
December 2024
Food Refrigeration and Computerized Food Technology (FRCFT), Agriculture and Food Science Centre, University College Dublin, National University of Ireland, Belfield, Dublin 4, Ireland.
Faba bean proteins are currently viewed as promising animal protein alternatives. However, certain functional properties e.g.
View Article and Find Full Text PDFLaminoplasty and In-Site Regrafting for the Treatment of Thoracic Ossification of the Ligamentum Flavum: A Surgical Technique.
Orthop Surg
January 2025
Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Article Synopsis
- The study evaluated a new surgical technique called laminoplasty and in-site regrafting (LPIR) for patients with thoracic ossification of the ligamentum flavum (TOLF), addressing issues like thoracic kyphosis and loss of spinal motion.
- Eight patients (3 males, 5 females, average age 52.87) underwent LPIR surgery between January 2019 and March 2024, with positive outcomes measured by pre- and post-operative pain and function scores.
- Results showed significant symptom alleviation, with a notable reduction in pain and improvement in overall functional scores post-surgery, indicating that LPIR is a safe and effective option for treating TOLF.
Nonlinear standing waves for assessing material nonlinearity in thin samples.
Ultrasonics
August 2024
School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
The second harmonic generation (SHG) technique offers a quantitative damage parameter known as the acoustic nonlinearity parameter (β) capable of detecting the change in the inherent material nonlinearity. However, current SHG methods, in particular, those used for measuring β in construction materials, have an unresolved issue in their application due to limited sample sizes. The restricted sample dimensions lead to the generation of boundary-reflected waves, which hinder the selective detection of propagating waves and thus the precise evaluation of material nonlinearity through β.
View Article and Find Full Text PDFA Novel Closed-Loop Electrical Brain Stimulation Device Featuring Wireless Low-Energy Ultrasound Power and Communication.
Neuromodulation
May 2024
Bionet Sonar, Newton, MA, USA.
Objectives: This study aimed to indicate the feasibility of a prototype electrical neuromodulation system using a closed-loop energy-efficient ultrasound-based mechanism for communication, data transmission, and recharging.
Materials And Methods: Closed-loop deep brain stimulation (DBS) prototypes were designed and fabricated with ultrasonic wideband (UsWB) communication technology and miniaturized custom electronics. Two devices were implanted short term in anesthetized Göttingen minipigs (N = 2).
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