We previously stated that blood filtrability was very decreased during 30 to 60 days after burn traums. After one week there is a significant relationship between the filtrability of the RBC and the burnt area. In the beginning of the phenomenon many factors seem to be involved: --intra-erythrocyte ATP variations,--hemodynamic disorders of the early shock,--disturbances of enzymatic systems of shock secondary-effect,--reactions related to the protidic catabolism. The elucidation of this mechanism though not essentially univocal, may be important of state for the therapeutic protocol in terms of tissus oxygenation, healing and grafting.
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Changes in erythrocyte deformability during day and possible role of melatonin.
Endocr Regul
January 2018
2Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Slovak Republic.
Objectives: The deformability of erythrocytes is their ability to change shape in order to pass through the capillaries. Th is is necessary for quality of microcirculation and sufficient delivery of oxygen to the tissues. Th e aim of our study was to investigate the possible spontaneous changes in the erythrocyte deformability during day and evaluation of the possible direct effects of melatonin (hormone involved in regulation of biorhythms) on the erythrocyte deformability.
View Article and Find Full Text PDFIn vitro effects of melatonin on the filtrability of erythrocytes in SNP-induced oxidative stress.
Clin Hemorheol Microcirc
October 2004
University of Erciyes, Medical Faculty, Department of Physiology, Kayseri, Turkey
Erythrocyte deformability is one of the most important charactheristics of erythrocytes for an effective microcirculatory function and is affected from a number of factors, including the oxidative-damage-induced by nitric oxide (NO). This study was performed to investigate the effects of in vitro melatonin incubation on the antioxidant status and deformability of erythrocytes in sodium nitroprusside (SNP), a nitric oxide donor, induced oxidative stress. 40 blood samples taken from the adult healthy people were divided into 4 groups randomly and incubated with saline, SNP (1 mM), melatonin (MEL, 1 mM), MEL + SNP and SNP + L-NAME (5 mM) respectively.
View Article and Find Full Text PDFThe assessment of erythrocyte deformability by filtration rate.
Bratisl Lek Listy
November 2003
Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
The aim of the study was to monitor the erythrocyte deformability as one of important factors securing the appropriate tissues perfusion in healthy subjects and diabetic patients with insulin dependent diabetes mellitus. Erythrocyte deformability was determined by the method of filtration and centrifugation, and the erythrocyte filtrability was calculated as a percentage of filtered erythrocytes out of the number of erythrocytes counted before centrifugation. Diluted blood suspensions were filtered by centrifugation through membrane filters with pores of 5 microm in diameter.
View Article and Find Full Text PDF[Effect of molsidomine on rheological parameters and the incidence of cardiovascular events].
Dtsch Med Wochenschr
June 2003
Abteilung Innere Medizin II, Universität Ulm.
Background And Objective: In-vitro studies revealed that nitric oxide (NO) may affect rheological parameters. We studied the effect of highly-dosed NO-donor molsidomine on blood rheology and the impact of rheological parameters on the incidence of severe cardiovascular events.
Patients And Methods: In this randomized, placebo-controlled and double-blind trial 166 patients (60 +/- 10 years) with stable angina pectoris and coronary intervention received molsidomine 3 x 8 mg t.
Involvement of erythrocyte aggregation and erythrocyte resistance to flow in acute coronary syndromes.
Clin Hemorheol Microcirc
November 1999
I. Medical Department, City Hospital, Ingolstadt, Germany.
The objective of the study was to identify the relative importance of erythrocyte flow resistance and aggregation in acute and chronic coronary syndromes. 117 subjects in five groups were studied: (1) 34 patients shortly after acute myocardial infarction (AMI) before reperfusion therapy; (2) 27 patients with unstable and (3) 21 with stable angina pectoris (AP); (4) 14 age-matched control patients and (5) 21 healthy volunteers. Single erythrocyte transit times were measured using the Cell Transit Analyser.
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