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Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective.
AAPS PharmSciTech
January 2025
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India.
Microneedles (MNs) appear as a transformative and minimally invasive platform for transdermal drug delivery, representing a highly promising strategy in wound healing therapeutics. This technology, entailing the fabrication of micron-scale needle arrays, enables the targeted and efficient delivery of bioactive agents into the epidermal and dermal layers without inducing significant pain or discomfort. The precise penetration of MNs facilitates localized and sustained drug release, which significantly enhances tissue regeneration and accelerates wound closure.
View Article and Find Full Text PDFBiologics in severe asthma: a state-of-the-art review.
Eur Respir Rev
January 2025
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Asthma is considered severe if it remains uncontrolled despite optimal conventional therapy, characterised by poor symptom control, frequent exacerbations and increased exposure to systemic corticosteroids. This has a significant impact on morbidity, mortality and healthcare resource utilisation. Recent advances in the understanding of asthma heterogeneity and immunopathogenesis have helped delineate precise disease pathways.
View Article and Find Full Text PDFDICCR: Double-gated intervention and confounder causal reasoning for vision-language navigation.
Neural Netw
December 2024
School of Computer and Electronic Information, Guangxi University, University Road, Nanning, 530004, Guangxi, China. Electronic address:
Vision-language navigation (VLN) is a challenging task that requires agents to capture the correlation between different modalities from redundant information according to instructions, and then make sequential decisions on visual scenes and text instructions in the action space. Recent research has focused on extracting visual features and enhancing text knowledge, ignoring the potential bias in multi-modal data and the problem of spurious correlations between vision and text. Therefore, this paper studies the relationship structure between multi-modal data from the perspective of causality and weakens the potential correlation between different modalities through cross-modal causality reasoning.
View Article and Find Full Text PDFDecellularization of fish tissues for tissue engineering and regenerative medicine applications.
Regen Biomater
November 2024
Zhejiang Top-Medical Medical Dressing Co. Ltd, Wenzhou, Zhejiang 325025, China.
Decellularization is the process of obtaining acellular tissues with low immunogenic cellular components from animals or plants while maximizing the retention of the native extracellular matrix structure, mechanical integrity and bioactivity. The decellularized tissue obtained through the tissue decellularization technique retains the structure and bioactive components of its native tissue; it not only exhibits comparatively strong mechanical properties, low immunogenicity and good biocompatibility but also stimulates neovascularization at the implantation site and regulates the polarization process of recruited macrophages, thereby promoting the regeneration of damaged tissue. Consequently, many commercial products have been developed as promising therapeutic strategies for the treatment of different tissue defects and lesions, such as wounds, dura, bone and cartilage defects, nerve injuries, myocardial infarction, urethral strictures, corneal blindness and other orthopedic applications.
View Article and Find Full Text PDFStudy on the path of clustering construction of rural primary schools' aesthetic education programs from the perspective of resource integration.
PLoS One
January 2025
College of Ecology and Environment, Baotou Teachers' College, Baotou, China.
Aesthetic education is an important part of the overall development of students. This study analyzes the number of rural schools and enrollment, number of classes, and number of full-time teachers in those schools from 2013 to 2022, and clarifies the current challenges in aesthetic education in rural elementary schools and the path of quality improvement. It then constructs a curriculum cluster model that shares resources, teachers, management, instructional design, and practical activities, etc.
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