The Pulmonary alveolar microlithiasis is a rare disease of unknown etiology with chronic course. Clinical symptoms are not characteristic or missing completely. The disease is diagnosed by X-ray examination and histologic examination from biopsy specimen of the lung. A report on the first case in Austria is given.
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Lung Function Decline in Pulmonary Alveolar Microlithiasis.
Cureus
November 2024
Pulmonary Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ITA.
Pulmonary alveolar microlithiasis (PAM) is a rare lung disorder characterized by calcium phosphate microliths in the alveolar spaces. Autosomal recessive mutations on the SLC34A2 gene lead to altered type IIb sodium phosphate cotransporter in alveolar type-II cells of the lung, thus resulting in aggregations of microliths in the alveoli. To date, more than 1000 cases have been reviewed by expert pulmonary clinicians.
View Article and Find Full Text PDFPulmonary Alveolar Microlithiasis in a Young Man Undergoing Lung Transplantation: A Case Report.
Int J Surg Pathol
July 2024
Department of Internal Medicine, Pulmonology Service. Fundación Valle del Lili, Cali, Colombia.
Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of microliths in the alveoli, attributed to mutations in the solute carrier family 34 member 2 () gene. Diagnosis is often incidental to chest imaging, most frequently occurring between the second and fourth decades of life. The disease follows a progressive course and manifests with a clinical-radiological dissociation.
View Article and Find Full Text PDFPulmonary alveolar microlithiasis combined with gastric mucosal calcification: a case report.
Front Med (Lausanne)
May 2024
The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Background: Pulmonary alveolar microlithiasis (PAM) is a rare disease whose clinical and imaging manifestations are non-specific, characterized by the deposition of microliths, which primarily consist of calcium and phosphorus, within the alveoli. In the cases of PAM, patients combined with calcification of other organs such as gastric mucosal calcification are less common.
Case Presentation: A 59-year-old woman was admitted to our hospital due to cough producing white, foamy sputum, accompanied by dyspnea and fever for 20 days.
Successful bilateral lung transplantation in pulmonary alveolar microlithiasis: A case report and review of literature.
Clin Respir J
May 2024
Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Background: Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive genetic disorder with approximately 1000 known cases worldwide, in which calcium phosphate microliths deposit in the alveolar air spaces. As of writing this report, no definitive conventional therapy exists, and many PAM cases may progress to severe respiratory failure and potential death. Bilateral lung transplantation (BLx) seems to be the most optimal solution; however, this procedure is challenging along with limited reports regarding the outcome in PAM.
View Article and Find Full Text PDFPulmonary Alveolar Microlithiasis in a Patient Requiring Allotransplant.
Mayo Clin Proc
June 2024
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN; Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN. Electronic address:
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