Examination of the action of different xenobiotics (pesticides, heavy metals) on embryogenesis and progeny allowed the methodological approaches to this line of research to be suggested. It is recommended that xenobiotics be administered in different periods of embryogenesis: from day 1 to day 7, from day 7 to day 15 and from day 1 to day 20. It has been established that at cross mating the most pronounced alterations arose in the progeny of experimental males. The main object was to study the effect dependence on the dose, time and administration of the substances in order to establish their threshold and subthreshold levels. Validation of these parameters required the use of a complex of integral, functional, biochemical and morpholgical findings that warrant as assessment of the changes from the standpoint of the entire body, individual systems, organs, cellular and subecellular structures.
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