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Compound-dependent fetal toxicity after in utero exposure to chemotherapy in a pregnant mouse model.
Environ Toxicol Pharmacol
December 2024
Department of Oncology, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, UZ Leuven, Leuven, Belgium; Gynecologic Oncology, Netherlands Cancer Institute, Anthony Van Leeuwenhoek, Amsterdam, the Netherlands. Electronic address:
Although chemotherapy is integrated in the treatment of second-trimester pregnant cancer patients, its potential cyto- and genotoxicity to fetal tissue remains unknown. To investigate any causal relation between in utero chemotherapy exposure and fetal toxicity, late-gestation pregnant BL6 mice were exposed to vehicle, or one of six chemotherapeutic compounds, used to treat pregnant cases: cyclophosphamide, carboplatin, cisplatin (alkylating agents), epirubicin, doxorubicin (anthracyclines) or paclitaxel (taxane). fetuses were euthanized at gestational day 18.
View Article and Find Full Text PDFThe risk of peripartum cardiomyopathy among pediatric, adolescent, and young adult cancer patients exposed to doxorubicin: an opinion article.
Front Oncol
November 2024
Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL, United States.
Effect of ethyl acetate extract from Usnea longissima on chemotherapy-associated multiple organ dysfunction in rats.
Biomed Pharmacother
December 2024
Department of Pathology, Faculty of Veterinary, Erciyes University, Kayseri 38280, Turkey. Electronic address:
Background: The toxic effects of doxorubicin and cisplatin in various organs have been associated with oxidative stress. Studies have shown that Usnea longissima has strong antioxidant effects. This study aimed to investigate the protective effect of ethyl acetate extract from Usnea longissima (ULE), which is known to have strong antioxidant effects, on chemotherapeutic-induced heart, kidney, liver, and ovarian toxicity.
View Article and Find Full Text PDFDevelopment and validation of an UPLC-ESI-MS/MS method for simultaneous quantification of antineoplastic agents and their metabolites in human plasma after unintentional exposure.
Arch Toxicol
January 2025
Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Article Synopsis
- A variety of commonly used cancer drugs like cyclophosphamide, daunorubicin, epirubicin, doxorubicin, and paclitaxel lack simultaneous measurement methods for their levels and metabolites in human plasma.
- The research developed a sensitive method using solid phase extraction, UPLC, and tandem mass spectrometry, validating it based on various criteria such as sensitivity and precision.
- The method was successfully tested on plasma samples from pregnant cancer patients, detecting cyclophosphamide concentrations, indicating its practical application for monitoring drug exposure.
Benefits of BV-AVD (Brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine) versus ABVD (doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine) in patients with advanced-stage Hodgkin's lymphoma: an analysis of the ECHELON 1 trial by the GATLA group using the Delphi Method.
Hematol Transfus Cell Ther
December 2024
Instituto Privado de Hematologia y Hemoterapia, Entre Ríos, Argentina.
Introduction: The BV-AVD (Brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine) combination for first-line treatment of advanced stage Hodgkin's lymphoma has been approved by regulatory authorities and included in international guidelines. However, several factors influence its incorporation as standard of care.
Materials And Methods: A group of experts from different institutions was identified and, using the Delphi method, an analysis of the results of the ECHELON 1 trial for the indication of BV-AVD over ABVD (doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine) in patients with Hodgkin's lymphoma Stages III and IV in Argentina was done.
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