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Use of full-thickness mesh grafts and full-thickness meek micrografts in five horses with ear skin defects caused by trauma or neoplasm resection.
Vet Surg
January 2025
University Equine Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Objectives: To report the management and outcomes of five horses with ear skin defects treated with the use of full-thickness mesh grafts and full-thickness Meek micrografts.
Animals: Five horses with acute or granulating pinna skin wounds.
Study Design: Short case series.
Triglyceride-glucose index as a marker for visceral obesity in patients with gastric cancer.
Front Nutr
January 2025
Department of Nutrition, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Background: The triglyceride-glucose (TyG) index has emerged as a validated and cost-effective indicator of insulin resistance (IR). Given the significant association between visceral obesity and IR, this study aimed to investigate the utility of the TyG index in estimating visceral obesity in patients with gastric cancer (GC).
Methods: The visceral fat area (VFA), subcutaneous fat area (SFA), and VFA-to-SFA ratio (VSR) were determined through the analysis of CT images at the lumbar 3 level.
ECM-mimicking hydrogel models of human adipose tissue identify deregulated lipid metabolism in the prostate cancer-adipocyte crosstalk under antiandrogen therapy.
Mater Today Bio
February 2025
School of Biomedical Sciences, Faculty of Health, and Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, QLD, 4102, Australia.
Antiandrogen therapies are effectively used to treat advanced prostate cancer, but eventually cancer adaptation drives unresolved metastatic castration-resistant prostate cancer (mCRPC). Adipose tissue influences metabolic reprogramming in cancer and was proposed as a contributor to therapy resistance. Using extracellular matrix (ECM)-mimicking hydrogel coculture models of human adipocytes and prostate cancer cells, we show that adipocytes from subcutaneous or bone marrow fat have dissimilar responses under the antiandrogen Enzalutamide.
View Article and Find Full Text PDFLipedema: exploring pathophysiology and treatment strategies - state of the art.
J Vasc Bras
January 2025
Instituto Lipedema Brasil, São Paulo, SP, Brasil.
Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved.
View Article and Find Full Text PDFQuantifying Knee-Adjacent Subcutaneous Fat in the Entire OAI Baseline Dataset - Associations with Cartilage MRI T, Thickness and Pain, Independent of BMI.
Osteoarthritis Cartilage
January 2025
Department of Radiology and Biomedical Imaging, University of California, San Francisco.
Objective: Knee-adjacent subcutaneous fat (kaSCF) has emerged as a potential biomarker and risk factor for OA progression. This study aims to develop an AI-based tool for the automatic segmentation of kaSCF thickness and evaluate the cross-sectional associations between kaSCF, cartilage thickness, MRI-based cartilage T relaxation time, knee pain, and muscle strength independent of BMI.
Design: Baseline 3.
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