The authors present an economical injector apparatus (Redon flask type) for double contrast barium enema examinations.
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J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Krakow, Poland; Department of Cardiac and Vascular Diseases, St. John Paul II Hospital, Krakow, Poland.
A considerable percentage of ineffective treatment in pulmonary arterial hypertension (PAH) may be related to subtherapeutic dosage or non-adherence. The aim of the study was to develop a simple analytical method suitable for plasma determination of selected drugs: riociguat (RIO), bosentan (BOS) and macitentan (MAC) administered to PAH patients. An isocratic HPLC-UV system (Spectra Physics - Shimadzu) with a manual injector (50 μL loop) was applied.
View Article and Find Full Text PDFMed Eng Phys
November 2024
Department of Mechanical Engineering, Hangzhou City University, Hangzhou, 310015, China.
To reveal the penetration mechanism and present the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, the present study conducted experimental research on high-speed water-jet penetration into ballistic gelatin. The free jet dynamics of an air-powered needle-free injector that can emit up to 1.
View Article and Find Full Text PDFBMJ Paediatr Open
November 2024
University of Southampton, Southampton, UK.
Objective: To investigate awareness and implementation of the Spare Pens (ie, adrenaline auto-injectors (AAIs)) scheme in primary and secondary schools in two regions in Wales.
Design: A cross-sectional pilot study employing a mixed research methods approach was carried out.
Setting And Participants: State primary and secondary schools within Swansea and Pembrokeshire regional authorities were invited to take part.
J Comp Eff Res
December 2024
Mallinckrodt Pharmaceuticals, Bridgewater, NJ 08807, USA.
The goal of this market research study was to determine the usability of a single-dose prefilled injector (SelfJect™) for administration of Acthar Gel (manufactured by Mallinckrodt Pharmaceuticals, UK) in patients with inflammatory diseases by obtaining feedback from patient and practitioner user groups in the US. Patients and healthcare professionals (HCPs) representing relevant therapeutic areas were enrolled in the study between February and March 2021. SelfJect was mailed to patients and HCPs prior to 90-min virtual video-recorded focus group sessions and 60-min 1:1 virtual interviews, respectively.
View Article and Find Full Text PDFZhongguo Yi Liao Qi Xie Za Zhi
September 2024
School of Mechanical Engineering, Zhejiang University, Hangzhou, 310000.
Needle-free jet injectors refer to a kind of medical device that uses a specific device to form a small, high-speed jet of medication to pierce the human skin, thereby achieving the delivery of medication into the human body without the use of needles. In the past few decades, needle-free jet injectors have undergone many changes with the development of healthcare systems and advancements in related technologies. In this article, the history, research status, and clinical application of needle-free jet injectors are introduced.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!