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Background: The growing number of people living with Alzheimer's disease and related dementias (ADRD) has led to an increased interest in the experiences of informal caregivers. Effective instruments to measure both negative and positive aspects of caregiving and validated with diverse caregiver populations, are needed to inform the design and evaluation of targeted interventions. This study (a) reviews extant literature on instruments developed to measure the range of roles and experiences of unpaid caregivers of people living with ADRD, (b) describes characteristics of the populations used to validate these instruments, and (c) discusses the usefulness, applicability, and generalizability of current measures METHOD: A scoping review was performed following the methodological framework of Aromataris and Munn (2020).

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Background: Aging is an inseparable part of life, accompanied by mild to severe cognitive disorders. This study aimed to investigate the influence of balance-based interventions on cognitive function in older adults, encompassing both healthy individuals and those with mild cognitive impairment (MCI).

Methods: A systematic review was conducted by searching multiple databases up to April 2023, and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist was followed for reporting.

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Purpose: This purpose of this article was to use the method of conceptual history to analyze the evolution of the concept of "validity" in nursing diagnoses and to identify key transformations, theoretical influences, and implications for contemporary clinical judgment and decision-making.

Methods: Five stages derivate from the approach proposed by Reinhart Koselleck, including: identify the concept and its relevance, historical contextualization, contextual use, semantic changes over time, and synthesis and interpretation.

Findings: The concept of "validity" in nursing diagnoses is essential for accurate diagnostics, interdisciplinary communication, and evidence-based decision-making, though its interpretation varies due to differing philosophical perspectives and methodological challenges.

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Background: The outcomes of varicocele repair (VR) for severe oligozooasthenoteratozoospermia (OAT) have not been widely examined.

Methods: Assessment of outcomes of VR after severe OAT, employing scoping review of published guidelines, and systematic review of literature. The Newcastle-Ottawa scale appraised the quality of included studies.

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The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies.

Int J Mol Sci

December 2024

Department of Anesthesiology and Intensive Care Medicine, Faculty of General Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Târgu Mureș, Romania.

Ropivacaine, a widely used regional anesthetic also used for pain management, has been increasingly used in recent years due to its increased efficacy and improved safety compared to similar anesthetics. Biomonitoring of ropivacaine and its metabolites during and after anesthesia is an essential process for ensuring therapeutic efficacy and safe usage for patients. The most useful biomonitoring tool in recent years has been liquid chromatography coupled with mass spectrometry (LC-MS/MS), which offers selectivity, sensitivity, as well as accuracy of measurements.

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