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Breast Morphogenesis: From Normal Development to Cancer.
Adv Exp Med Biol
January 2025
Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
The human breast gland is composed of branching epithelial ducts that culminate in milk-producing units known as terminal duct lobular units (TDLUs). The epithelial compartment comprises an inner layer of luminal epithelial cells (LEP) and an outer layer of contractile myoepithelial cells (MEP). Both LEP and MEP arise from a common stem cell population.
View Article and Find Full Text PDFDiagnostic and therapeutic approach to endobronchial metastases from extra-thoracic neoplasms: A report of three cases and brief review of literature.
Tunis Med
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, Mongi Slim La Marsa University Hospital, Department of Pulmonology and Allergology, Tunis, Tunisia.
Introduction: Endobronchial metastases (EBMs) are rare, with primary tumours predominantly of breast, renal, and colorectal origin. Bronchoscopy is the diagnostic gold standard, with histological confirmation through immunohistochemical study.
Cases: We presented three cases of EBMs, one secondary to colorectal cancer and two associated with renal tumours.
Primary Breast Malignancy in Children and Adolescents: A Population-Based Study.
Breast J
January 2025
Department of Pediatric Intensive Care Unit, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China.
Article Synopsis
- Primary breast cancer in children and adolescents is rare and has distinct characteristics compared to adult cases, necessitating a study to predict survival rates in this population.
- The study analyzed 115 pediatric patients, primarily focusing on demographic data and tumor characteristics, finding significant predictors of overall survival (OS) to be the SEER and M stages of cancer.
- A nomogram was developed to aid in predicting OS, addressing a gap in research by providing comprehensive insights into pediatric breast cancer prognosis.
Management of Ductal Carcinoma In Situ: An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline.
Curr Oncol
December 2024
Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G2M9, Canada.
(1) Background: To make recommendations on the most effective therapy options for Ductal Carcinoma of the Breast (DCIS) patients; (2) Methods: MEDLINE, EMBASE, Cochrane Library, PROSPERO databases, and main relevant guideline websites were searched. Draft versions of the guideline went through formal internal and external reviews, with a final approval by the Program in Evidence Based Care and the DCIS Expert Panel. The Grading of Recommendations, Assessment, Development, and Evaluation approach was followed; (3) Results: Based on the current evidence from the systematic review and this guideline authors' clinical opinions, initial draft recommendations were developed to improve the management of patients with DCIS.
View Article and Find Full Text PDFCausal Relationship and Potential Common Pathogenic Mechanisms Between Alopecia Areata and Related Cancer.
Clin Cosmet Investig Dermatol
December 2024
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Objective: Alopecia areata (AA) is an autoimmune skin disease. Observational studies have reported an association between AA and cancer. However, the causal relationship between AA and cancer has not been reported.
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