A particularly important potential value of the Dynamic Spatial Reconstructor approach is that all the above data will be obtainable from a single injection of contrast agent into the right ventricle or pulmonary artery. On the basis of preliminary experimental data, a concentration of at least 80 mg of iodine per ml of contrast agent should be present in the aortic root for adequate opacification of the coronary arteries and myocardium; a bolus of at least 0.5 ml of contrast medium per kg, injected into the venous circulation, is required. As high-speed, volumetric imaging, computed tomographic scan machines such as the Dynamic Spatial Reconstructor become available with higher density resolution, perhaps a single injection of contrast agent into the right atrium or even a peripheral vein may be adequate to obtain all these measurements.
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PLoS Comput Biol
January 2025
Complex Systems Research Center, Shanxi University, Taiyuan, Shanxi, China.
Human mobility between different regions is a major factor in large-scale outbreaks of infectious diseases. Deep learning models incorporating infectious disease transmission dynamics for predicting the spread of multi-regional outbreaks due to human mobility have become a hot research topic. In this study, we incorporate the Graph Transformer Neural Network and graph learning mechanisms into a metapopulation SIR model to build a hybrid framework, Metapopulation Graph Transformer Neural Network (M-Graphormer), for high-dimensional parameter estimation and multi-regional epidemic prediction.
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January 2025
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Motor cortical high-gamma oscillations (60-90 Hz) occur at movement onset and are spatially focused over the contralateral primary motor cortex. Although high-gamma oscillations are widely recognized for their significance in human motor control, their precise function on a cortical level remains elusive. Importantly, their relevance in human stroke pathophysiology is unknown.
View Article and Find Full Text PDFAstrobiology
December 2024
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Agent-based simulations are set to describe the early biotic selection of oligomers made of monomers of different chirality. The simulations consider the spatial distribution of agents and resources, the balance of biomass of different chirality, and the balance of chemical energy. Following the well-known Wald's hypothesis, a disadvantage is attributed to the change in chirality along the biochemical sequence.
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January 2025
Laboratoire des Systèmes Perceptifs, Département d'études cognitives, École normale supérieure, PSL University, France.
Visual perception has been described as a dynamic process where incoming visual information is combined with what has been seen before to form the current percept. Such a process can result in multiple visual aftereffects that can be attractive toward or repulsive away from past visual stimulation. A lot of research has been conducted on what functional role the mechanisms that produce these aftereffects may play.
View Article and Find Full Text PDFStem Cell Rev Rep
January 2025
Department of Integrative Biology, Gene Therapy Laboratory, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, TN, 632 014, India.
Hematopoietic stem cells are a unique population of tissue-resident multipotent cells with an extensive ability to self-renew and regenerate the entire lineage of differentiated blood cells. Stem cells reside in a highly specialized microenvironment with surrounding supporting cells, forming a complex and dynamic network to preserve and maintain their function. The survival, activation, and quiescence of stem cells are largely influenced by niche-derived signals, with aging niche contributing to a decline in stem cell function.
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