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Qualitative comparison of decalcifiers for mouse bone cryosections for subsequent biophotonic analysis.
Sci Rep
January 2025
Leibniz Institute of Photonic Technology (Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research, LPI), 07745, Jena, Germany.
Bone tissue, with its complex structure, often necessitates decalcification of the hard tissue for ex vivo morphological studies. The choice of a suitable decalcification method plays a crucial role in preserving desired features and ensuring compatibility with diverse imaging techniques. The search for a universal decalcification method that is suitable for a range of biophotonic analyses remains an ongoing challenge.
View Article and Find Full Text PDFProximity to Explosive Synchronization Determines Network Collapse and Recovery Trajectories in Neural and Economic Crises.
bioRxiv
December 2024
Department of Anesthesiology, Center for Consciousness Science, Neuroscience Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan, USA.
When complex systems move away from criticality-a balance between order and chaos-they are no longer optimized. Furthermore, when criticality is lost too quickly, or recovery is delayed, system damage can result. However, the mechanism for these abnormally fast or slow critical transitions remains unknown.
View Article and Find Full Text PDFPrognostic Value of ISS and TRISS Scores in Tunisian Terrorism Victims.
Mil Med
October 2024
Research Unit UR17DN05, Military Hospital of Tunis, Montfleury, Tunis 1008, Tunisia.
Introduction: Injuries caused by terrorism attacks are one of the urgent problems of the society and the health system. In this work, we aimed to assess the injury severity score (ISS) and trauma injury severity score (TRISS) in Tunisian military combatants injured during terrorism attacks.
Materials And Methods: A total of 153 victims of terrorism admitted to the Military Hospital of Tunis between January 2012 and January 2017 were included.
Transdermal Drug Delivery Systems (TDDS): Recent Advances and Failure Modes.
Mol Pharm
November 2024
Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland 4102, Australia.
Transdermal drug delivery systems (TDDS), commonly refered to as "patches", present a nonintrusive technique to provide medication without the need for invasive procedures. These products adhere to the skin and gradually release a specific dosage of medicine at a defined rate into the bloodstream. Compared with other methods of drug delivery, TDDS offer benefits such as reduced invasiveness, convenience for patients, and avoidance of the metabolic processes that occur when drugs are orally consumed.
View Article and Find Full Text PDFTemporal trends and treatment patterns in anal fissure management: insights from a multicenter study in Italy.
Tech Coloproctol
October 2024
Oncology and Gastroenterology - DiSCOG, University of Padova, Padua, Italy.
Article Synopsis
- A multicenter study by the Italian Society of Colorectal Surgery examined treatment trends for anal fissures (AF) over a decade, focusing on various treatment approaches based on AF presentation and sphincter function.
- Data from 22,016 patients showed significant variability in treatment methods influenced by factors like symptom duration and surgeon preference, with conservative treatments being the most common.
- The study emphasizes the evolving nature of AF management and calls for more research to identify the best treatment strategies for improved patient outcomes.
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