Spermatozoa were collected from the rat caput epididymidis by micropuncture and their motility assessed after dilution in physiological saline containing carnitine or related compounds. L(+)-Carnitine caused, 2 min after dilution, a transient stimulation of the motility of spermatozoa with low initial motility. No stimulatory effects were seen on spermatozoa which had high initial motility. The D-isomer inhibited the motility of spermatozoa with high initial motility after 2 min and all compounds tested appeared to inhibit, at 20 min after dilution, the motility of spermatozoa with high initial motility. Acetyl-L-carnitine and acetyl-D-carnitine stimulated the motility of spermatozoa with low initial motility. This study suggests that carnitine may be important in the development by spermatozoa of the potential for motility and also to maintain mature spermatozoa in a quiescent state.
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