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Innate immune memory in chronic HIV and HIV-associated neurocognitive disorders (HAND): potential mechanisms and clinical implications.
J Neurovirol
December 2024
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA.
Although antiretroviral therapy (ART) has dramatically improved the outlook of the HIV/AIDS pandemic, people living with HIV (PLWH) on suppressive therapy are still at higher risk for a range of comorbidities including cardiovascular disease (CVD) and HIV-associated neurocognitive disorders (HAND), among others. Chronic inflammation and immune activation are thought to be an underlying cause of these comorbidities. Many of the factors thought to drive chronic inflammation and immune activation in HIV overlap with factors known to induce trained immunity.
View Article and Find Full Text PDFPlant Coumarin Metabolism-Microbe Interactions: An Effective Strategy for Reducing Imidacloprid Residues and Enhancing the Nutritional Quality of Pepper.
J Agric Food Chem
December 2024
Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Danzhou, Hainan 570228, PR China.
Imidacloprid (IMI) stress positively correlates with the potential of coumarins to alleviate abiotic stress. However, little is known about the pathways and mechanisms by which coumarin reduces the IMI residue by regulating plant secondary metabolism and plant-microbe interactions. This study examined the impact of coumarin on the uptake, translocation, and metabolism of IMI in pepper plants by modulating the signal molecule levels and microbial communities in the rhizosphere and phyllosphere.
View Article and Find Full Text PDFImproved Control of Triple-Negative Breast Cancer Tumor and Metastasis with a pH-Sensitive Hyaluronic Acid Nanocarrier for Doxorubicin Delivery.
ACS Biomater Sci Eng
December 2024
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
Polymer based nanoformulations offer substantial prospects for efficacious chemotherapy delivery. Here, we developed a pH-responsive polymeric nanoparticle based on acidosis-triggered breakdown of boronic ester linkers. A biocompatible hyaluronic acid (HA) matrix served as a substrate for carrying a doxorubicin (DOX) prodrug which also possesses natural affinity for CD44 cells.
View Article and Find Full Text PDFExploring the potential of soapstock over a glycerol in vitamin K2 production by Bacillus subtilis natto: a comparative analysis.
Microb Cell Fact
December 2024
Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, 1417864411, Iran.
Background: Vitamin K2 is an essential nutrient for blood coagulation and cardiovascular health and mainly produced by bacteria strain like B. subtilis. researchers have explored producing strain improvement, cultivation mode, environmental optimization, increased secretion, and using cheaper carbon and nitrogen sources in order to increase vitamin K2 productivity.
View Article and Find Full Text PDF3D printing of continuous cotton thread reinforced poly (lactic acid).
Sci Rep
December 2024
Key Laboratory of Special Engineering Equipment Design and Intelligent Driving Technology, Guilin University of Aerospace Technology, Guilin, 541004, China.
This paper purposed to prepare poly (lactic acid)/continuous cotton thread (PLA /CCT) filaments by using prepreg method, and investigated the properties of PLA/CCT filament and their 3D printed composites. Firstly, a prepreg device was home-made to immerse CCT with PLA melts. The effects of the dragging speed and tensioning equipment on the quality of PLA/CCT filament was investigated.
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