1. Ventilation was recorded in thirty term infants during the first week after delivery using the trunk plethysmograph, during periods of rapid eye movement sleep (r.e.m.) and quiet sleep (n.r.e.m.). 2. Continuous histograms of tidal volume (VT) and instantaneous respiration rate (f) were samples at 0.5 sec intervals, passed through a digital filter to remove long-term trends in the data, and then subjected to frequency analysis. 3. In all the infants oscillations in VT and f were detected, with mean periods varying from 6.7 to 12.5 sec. The amplitude of these oscillations was higher during r.e.m. than n.r.e.m. sleep in all the infants. 4. The oscillations in VT tended to be out of phase with those for f, particularly during n.r.e.m. sleep; this contrasted with in-phase oscillations in VT and f found during periodic breathing in an additional six premature infants studied.
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http://dx.doi.org/10.1113/jphysiol.1978.sp012559 | DOI Listing |
Pediatr Neonatol
December 2024
Department of Pediatrics, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street District 5, Ho Chi Minh City, 700000, Viet Nam; University Medical Center Ho Chi Minh City, 215 Hong Bang Street District 5, Ho Chi Minh City, 700000, Viet Nam; Neonatal Intensive Care Unit, Children's Hospital 2, 14 Ly Tu Trong Street District 1, Ho Chi Minh City, 700000, Viet Nam. Electronic address:
Background: Invasive mechanical ventilation in very-low-birth-weight infants (VLBWI) was associated with immediate and long-term complications. Nasal high-frequency oscillation (nHFO) has recently become a new non-invasive ventilation (NIV) mode for treating respiratory failure in VLBWI. This study aimed to investigate the safety and efficacy of nHFO as an alternative respiratory support to prevent intubation in VLBWI.
View Article and Find Full Text PDFmedRxiv
December 2024
Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of language delays, the neurobiology underlying such language challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands in 3-to-6-month-old infants with an autistic sibling, followed by accelerated increases in power with age.
View Article and Find Full Text PDFAACE Clin Case Rep
July 2024
Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Background/objective: Fanconi-Bickel Syndrome (FBS) is an inherited disorder of glucose metabolism resulting from functional loss of glucose transporter 2 characterized by fasting hypoglycemia oscillating with postprandial hyperglycemia. Dysglycemia treatment strategies during FBS pregnancy have not been reported, and insulin therapy carries significant risk due to fasting hypoglycemia in FBS. We report for the first time: (1) glycemic profiles obtained via continuous glucose monitoring (CGM), (2) CGM-guided strategies for cornstarch and nutritional therapy for fasting hypoglycemia and postprandial hyperglycemia, respectively, and (3) placental glucose transporter 2 isoform expression in a pregnant individual with FBS.
View Article and Find Full Text PDFJ Exp Child Psychol
December 2024
Child Psychopathology Unit, Scientific Institute, 23842 Bosisio Parini, Lecco, Italy.
The ability to process auditory information is one of the foundations of the ability to appropriately acquire language. Moreover, early difficulties in basic auditory abilities have cascading effects on the appropriate wiring of brain networks underlying higher-order linguistic processes. Language impairments represent core difficulties in two different but partially overlapping disorders: developmental language disorder (DLD) and autism spectrum disorder (ASD).
View Article and Find Full Text PDFPediatr Pulmonol
January 2025
Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Background: There has been conflicting evidence regarding the impact of mode of delivery on respiratory outcomes in later childhood and adulthood. It is possible labor status, rather than mode of delivery, influences later respiratory morbidity. We hypothesized that extremely premature infants born to mothers in labor would have better lung function at follow-up than those born to mothers not in labor.
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