Twenty-three patients aged five to 52 years with good clinical histories of severe systemic reactions to hymenoptera stings confirmed by skin tests and RAST levels were treated with specific insect venoms. A more conventional, slow, bi-weekly schedule was used to determine whether they could be as successfully treated as those in earlier studies employing the "Rush desensitization" approach. It was also hoped these subjects would experience fewer untoward reactions. Comparisons of IgG (anti-hyaluronidase and phospholipase) levels pretreatment and after top dose (100 mcg) in all cases showed greater than three-fold rise, indicating protection. RAST IgE rose in most cases and plateaued by six months. Nineteen patients were restung to verify protection. Untoward reactions to injections were low (13%) and easily controlled. The authors conclude that the use of specific freeze dried insect venoms in a slow dose schedule is safe and effective in protecting severely sensitized individuals.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Host size overrides maternal effects on the development of a secondary hyperparasitoid wasp.
J Insect Sci
January 2025
Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands.
Unraveling the numerous factors that drive phenotypic variation in trait expression among animals has long presented a significant challenge. Whereas traits like growth and adult size are often heritable and are passed on from one generation to the next, these can be significantly affected by the quality and quantity of resources provided by one or both parents to their offspring. In many vertebrates, such as birds and mammals, parents raise their young until adult, providing food, shelter, and protection.
View Article and Find Full Text PDFGsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury.
PLoS One
January 2025
School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). Exercise training is a conventional physical therapy after SCI, but exercise intervention alone may have limited efficacy in reducing secondary injury and promoting nerve regeneration and functional remodeling. Our previous research found that intramedullary pressure after SCI is one of the key factors affecting functional prognosis.
View Article and Find Full Text PDF[Progress of researches on antiparasitic activities of scorpion venoms and their antimicrobial peptides].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2024
Mongolian Medical College, Inner Mongolia Minzu University; National Medical Products Administration Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), Tongliao, Inner Mongolia 028043, China.
Scorpion venom is a highly complicated cocktail of bioactive components including mucoproteins, enzymes, lipids, bioactive peptides, and other organic or inorganic molecules. Scorpion venom antimicrobial peptides are a class of small-molecule bioactive peptides extracted from scorpion venoms, which have shown a variety of biological activities, including antiviral, antibacterial, antifungal and antitumor actions. This review describes the progress of researches on the antiparasitic activities of scorpion venoms and their antimicrobial peptides, so as to provide insights into the research and development of novel antiparasitic agents.
View Article and Find Full Text PDFEvaluating the antibacterial efficacy of bee venom against multidrug-resistant pathogenic bacteria: Escherichia coli, Salmonella typhimurium, and Enterococcus faecalis.
World J Microbiol Biotechnol
January 2025
Microbiology, Botany Department, Faculty of Agriculture, Tanta University, Tanta City, 31527, Egypt.
Bee venom (BV) represents a promising natural alternative to conventional antibiotics, particularly significant given its broad-spectrum antimicrobial activity and potential to address the growing challenge of antimicrobial resistance. The prevalence of antimicrobial-resistant microorganisms (AMR) is a global burden that affects human health and the economies of different countries. As a result, several scientific communities around the world are searching for safe alternatives to antibiotics.
View Article and Find Full Text PDFPhytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment.
Int J Nanomedicine
January 2025
Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
Purpose: Mastoparan-M (Mast-M) has cytotoxic effects on various tumor cells in vitro, including liver cancer and colorectal cancer. However, the anti-tumor mechanism of Mast-M remains unclear and its potential for anti-tumor therapy has not been investigated. Herein, we aimed to develop a novel phytosome formulation loaded with Mast-M and evaluate its efficacy against breast cancer both in vitro and in vivo.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!