Forty seven patients and 26 healthy subjects controls were followed up in the course of 8 years. Twenty fine from the diabetic patients were without vaso-active medication and 22--treated with various vaso-active drugs (Hydrosarpan 711, Eleparon, Radecol, Padutin, Trental, etc.). The clinical approach was made use of for the periodical controls as well as non invasive methods with 60 channel ECG "Hellige" apparatus, electronic device "Dopton" oscillograph "Gesenius--Keller", double rheograph "Shulfrid", tastotherm P-60 "Braun", contact skin thermography according to Trikoir. A complex of functional tests was also applied. A statistically significant decrease (P < 0,001) ws established to develop in 83,9 per cent of the diabetic patients without vaso-active medication versus 47.6 per cent of those with medication and 11.5 per cent in the controls. The lesions of the lower limbs get significantly ahead (P < 0.05) of the coronary lesions both in frequency and evolution. The existing so far pessimism about the therapeutic effect of diabetic macroangiopathy is admitted not to be fully reasonable.
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