Repeated oral toxicity was assayed in albino rats of either sex, receiving every day 70 mg/kg of Ramrod for 4 months (group I) and everyday, but on alternate weeks-140 mg/kg (group II). A third experimental group of animals received daily 70 mg/kg of Ramrod on alternate weeks for 8 months. In comparison with the respective pure control groups of rats, those receiving monotonous treatment has the most liver function changes. Both intermittent schedules induced a phasic pattern in the adjustment processes: the response to intermittent administration of 70 mg/kg Ramrod was that of physiologic compensation. Periodic application of the herbicide for plant protection should be preferred, in view of prevention from progessional poisoning.
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