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Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement.
J Invasive Cardiol
November 2014
Cardiovascular Center, Rakuwakai Otowa Hospital, Kyoto, 2, Otowachinji-cho, Yamashina-ku, Kyoto, 607-8062, Japan.
Background: The interaction between caffeine and adenosine is still a matter of debate.
Aims: We examined whether caffeine attenuated intravenous adenosine-induced hyperemia in the measurement of fractional flow reserve (FFR) and whether an increased dose of adenosine overcame the caffeine antagonism.
Methods: FFR was measured using different adenosine doses (140, 175, and 210 μg/kg/min) and papaverine as a reference standard in patients with intermediate coronary stenoses, who refrained from caffeine for >24 h (no-caffeine group; n = 14) and those who consumed caffeine (caffeine group; n = 28).
Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons.
J Neurophysiol
May 2009
Department of Anatomy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
T1r3 is a critical subunit of T1r sweet taste receptors. Here we studied how the absence of T1r3 impacts responses to sweet stimuli by taste neurons in the nucleus tractus solitarius (NTS) of the mouse. The consequences bear on the multiplicity of sweet taste receptors and how T1r3 influences the distribution of central gustatory neurons.
View Article and Find Full Text PDFAssessment of renal flow and flow reserve in humans.
J Am Coll Cardiol
February 2006
Cardiovascular Centre Aalst, OLV-Clinic, Aalst, Belgium.
Objectives: The purpose of this work was to establish the normal range of maximal renal hyperemic response in humans and to identify the ideal renal vasodilatory stimuli.
Background: Stenotic renovascular atherosclerosis is increasingly treated by percutaneous transluminal renal intervention but with an unpredictable outcome. This may be due to hemodynamically non-significant stenosis or the presence of irreversible damage to the glomerular circulation.
Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting.
Eur J Cardiothorac Surg
November 2004
Department of Cardiovascular Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahokugun, Ishikawa 920-0265, Japan.
Objective: The internal thoracic artery (ITA) is a useful conduit for coronary artery bypass grafting (CABG) and the patency rate is indispensable. Recently we have developed a method for increasing ITA blood flow during surgery by directly injecting phosphodiesterase III inhibitor (PDE III-I) into the left ITA (LITA) to prevent its contracture. In this study, we compared the reactivity of LITA blood flows before and after injection of four drugs: saline, papaverine hydrochloride, isosorbide dinitrate (ISDN), and PDE III-I.
View Article and Find Full Text PDFCrystal structure of a shark single-domain antibody V region in complex with lysozyme.
Science
September 2004
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.
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