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A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin.
J Postgrad Med
October 2024
Department of Clinical Pharmacology and Therapeutics, NIMS, Hyderabad, Telangana, India.
Background: Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication in diabetic mellitus patients due to chronic hyperglycemia, resulting in platelet hyperactivity and dyslipidemia. Alpha-lipoic acid (ALA) is a potent antioxidant which has antiplatelet activity and lipid-modulating characteristics and plays a major role in the prevention of disease progression.
Aim: To evaluate the effect of ALA on inhibition of platelet aggregation and lipid profile.
The ameliorative potential of platelet-rich plasma and exosome on renal ischemia/reperfusion-induced uremic encephalopathy in rats.
Sci Rep
November 2024
Department of Biochemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Article Synopsis
- - The study investigates the effects of platelet-rich plasma (PRP) and exosome injections on kidney and brain tissue following renal ischemia/reperfusion (I/R) injury, which disrupts the blood-brain barrier and elevates toxins leading to uremic encephalopathy.
- - Results show that rats treated with PRP and exosomes exhibited improved kidney function, increased brain GABA levels, decreased glutamate, and better histological outcomes, compared to those that only experienced I/R injury.
- - Additionally, the treatments led to reduced oxidative stress and inflammation markers in renal tissues, as well as significant restoration of damaged brain cells, indicating their potential as therapeutic options for kidney-related brain injuries.
Effects of dietary supplementation of different levels of gamma-aminobutyric acid on reproductive performance, glucose intolerance, and placental development of gilts.
J Anim Sci
January 2024
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology, Tianjin 300308, China.
This study aimed to investigate the effects of dietary gamma-aminobutyric acid (GABA) supplementation on reproductive performance, glucose intolerance, and placental development of gilts during mid-late gestation. Based on the principle of backfat thickness consistency, 124 gilts at 65 d of gestation were assigned to three dietary groups: CON (basic diet, n = 41), LGABA (basic diet supplemented with 0.03% GABA, n = 42), and HGABA (basic diet supplemented with 0.
View Article and Find Full Text PDFPDGF-BB-Dependent Neurogenesis Buffers Depressive-Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus.
Adv Sci (Weinh)
August 2023
Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hippocampal circuitry stimulation is sufficient to regulate adult hippocampal neurogenesis and ameliorate depressive-like behavior, but its underlying mechanism remains unclear. Here, it is shown that inhibition of medial septum (MS)-dentate gyrus (DG) circuit reverses the chronic social defeat stress (CSDS)-induced depression-like behavior. Further analysis exhibits that inhibition of gamma-aminobutyric acidergic neurons in MS projecting to the DG (MS -DG) increases the expression of platelet-derived growth factor-BB (PDGF-BB) in somatostatin (SOM) positive interneurons of DG, which contributes to the antidepressant-like effects.
View Article and Find Full Text PDFPulmonary infection and baseline mRS scores predict poor prognosis in anti-GABAR encephalitis.
Front Immunol
September 2022
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Purpose: Anti-gamma-aminobutyric-acid type B receptor (anti-GABAR) encephalitis is a rare autoimmune condition caused by the presence of GABAR antibodies in the limbic system. However, its clinical features and prognostic factors are poorly understood. In this study, we aimed to explore factors that affect the response to first-line treatment in patients with anti-GABAR encephalitis.
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