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and activity of 1,2,3,4,6-O-pentagalloyl-glucose against .
Antimicrob Agents Chemother
January 2025
Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Invasive fungal infections have become an increasingly serious threat to global human health, underscoring the urgent need for the development of new antifungal drugs. In this study, we found a natural polyphenolic compound 1,2,3,4,6-O-pentagalloyl-glucose (PGG), which is present in various plants and herbs. PGG showed broad-spectrum antifungal activities, enhancing the efficacy of fluconazole.
View Article and Find Full Text PDF[Amphotericin B Liposomal Lock Therapy in Fungal Peritonitis in a Patient With Peritoneal Dialysis: Regarding a Challenging Case].
Rev Med Chil
September 2024
Unidad de Diálisis Peritoneal, Departamento de Nefrología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Fungal peritonitis is a rare complication associated with peritoneal dialysis, whose standard management consists of systemic antifungal therapy associated with early removal of the peritoneal dialysis catheter. This report describes and analyzes the use of lock therapy with intracatheter liposomal amphotericin B in a clinical case of fungal peritonitis.
View Article and Find Full Text PDFNovel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application.
J Fungi (Basel)
January 2025
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Fungal infections have become a growing concern in healthcare, particularly in immunocompromised individuals, with species like , , and posing significant challenges due to rising resistance and limited treatment options. In response, novel antifungal agents are being explored, including thiazolyl hydrazones. This study focuses on the development of a novel thiazolylhydrazone derivative, RW3.
View Article and Find Full Text PDFDual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Fermentation Broth in Treating Vulvovaginal Candidiasis.
J Fungi (Basel)
December 2024
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.
Vulvovaginal candidiasis (VVC), a condition predominantly caused by , affects millions of women worldwide, prompting the need for alternative treatments due to the side effects and increasing resistance associated with conventional imidazole antifungals. This study investigated VAGINNE, a novel fermentation broth derived from species, as a potential VVC treatment. Using a BALB/c mouse model of infection, we evaluated VAGINNE's effects on vaginal microbiome composition, inflammatory markers, and tissue integrity.
View Article and Find Full Text PDFLayer-by-Layer Biopolymer-Coated Deformable Liposomes-In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal.
Gels
December 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
Itraconazole (ITZ) is a potent antifungal agent. Its oral administration is associated with systemic toxicity, and its efficacy in ocular formulations is limited. This study aims to enhance ITZ's ocular permeation and antifungal efficacy by loading it into deformable liposomes (DLs) based on Tween 80 (T) or Poloxamer 188 (P).
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