The concentration of various substances were measured in renal and cardiac lymph and arterial and venous plasma to determine if lymph constituents might indicate events occurring at the cellular level in these two organs. The study utilized anesthetized dogs. Magnesium, calcium, pyruvate and glucose concentrations were similar in the four fluids. Cardiac lymph contained significantly higher concentrations of creatine phosphokinase, lactic dehydrogenase and lactate. Renal lymph contained lower concentrations of zinc and protein while both renal and cardiac lymph contained less copper than arterial plasma. Venous plasma contained more copper than the other fluids. It is concluded that lymph composition reflects events occurring in the cells, especially for substances that are not readily diffusable through blood capillary endothelium.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Kawasaki disease (KD) is a leading cause of acquired heart disease in children, often resulting in coronary artery complications such as dilation, aneurysms, and stenosis. While intravenous immunoglobulin (IVIG) is effective in reducing immunologic inflammation, 10-15% of patients do not respond to initial therapy, and some show resistance even after two consecutive treatments. Predicting which patients will not respond to these two IVIG treatments is crucial for guiding treatment strategies and improving outcomes.
View Article and Find Full Text PDFLow-grade endometrial endometrioid carcinoma of the p53-abnormal group: case presentation and diagnostic issues.
Pathologica
October 2024
Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy.
P53-abnormal endometrial carcinomas are high-grade and aggressive tumors which should be treated with chemo-/radiotherapy. In low-grade endometrioid carcinoma (LGEC), abnormal expression of p53 is an exceptional finding and is typically accompanied by patchy p16 positivity and diffuse hormone receptor expression. Herein, we report a case of LGEC exhibiting both p53 and p16 overexpression, highlighting the diagnostic pitfalls related to such phenotype.
View Article and Find Full Text PDFComparison of diagnostic performance of [Ga]-Ga-FAPI-46 and [F]-FDG PET/CT imaging for the detection of lesions and disease staging in patients with breast cancer.
Asia Ocean J Nucl Med Biol
January 2025
Research Center for Nuclear Medicine, Shraiati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study aimed to compare the effectiveness of [Ga]-Ga-FAPI-46 and [F]-FDG PET/CT imaging in detecting lesions and staging breast cancer.
- Twelve female breast cancer patients underwent both imaging tests, revealing that while both methods had similar overall lesion detection rates and disease staging, [Ga]-Ga-FAPI-46 indicated an improved tumor-to-background ratio and showed better uptake in certain areas like the brain and lymph nodes for some patients.
- The preliminary findings suggest that [Ga]-Ga-FAPI-46 may offer advantages in identifying tumors due to its lower uptake in healthy organs, potentially leading to more effective diagnostic applications in the future.
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging.
Toxicol Appl Pharmacol
December 2024
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:
Introduction: Accurate staging of malignancies often requires comprehensive evaluation of lymph nodes. However, finding these lymph nodes during oncological surgery is a daunting and time-consuming task, which increases the risk of missed lymph nodes and complications. Near-infrared (NIR) fluorescence imaging with the experimental fluorescent contrast agent PanLN800(-Forte) could provide real-time identification of lymph nodes and may solve this longstanding problem.
View Article and Find Full Text PDFA case report: Endobronchial ultrasound guided biopsy of radiographically normal size thoracic lymph nodes supporting diagnosis of cardiac sarcoidosis.
Respir Med Case Rep
November 2024
Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Article Synopsis
- Sarcoidosis is a rare chronic disease with an unclear cause, making cardiac sarcoidosis (CS) diagnosis particularly challenging.
- Current guidelines for diagnosing CS lack clinical validation, and while endomyocardial biopsy is specific, it is not very sensitive and has significant risks.
- A case study of a 63-year-old man diagnosed with CS through endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) of normal lymph nodes suggests that EBUS TBNA could be a viable option for diagnosing CS in cases without clear pulmonary sarcoidosis evidence.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!