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Deadly Nightshade (Atropa belladonna) and Other Weed Poisonings in the Pediatric Intensive Care Unit: Analysis of 54 Children.
Turk Arch Pediatr
November 2024
T. C. University of Health Sciences, Van Training and Research Hospital, Pediatrics Clinic, Van, Türkiye.
Article Synopsis
- The study focused on analyzing cases of poisoning from Atropa belladonna (deadly nightshade) among children, reviewing records from January 2010 to January 2022.
- Out of 54 children admitted for poisoning, 24 (44.4%) cases were due to deadly nightshade, presenting symptoms like flushing, vomiting, and severe cases requiring mechanical ventilation.
- The research highlighted key differences in symptom severity between deadly nightshade and other weed poisonings, with significant effects on ICU stay duration and respiratory support needs, yet no fatalities were reported.
Severe Neurotoxicity due to Poisoning: A Case Report and Literature Review.
Case Rep Neurol Med
September 2024
Article Synopsis
- Deadly nightshade, a poisonous plant from the Solanaceae family, contains toxic alkaloids with anticholinergic properties that can lead to serious health issues when ingested or contacted.
- The report details two cases of accidental poisoning from the raw leaves of the plant, where patients exhibited symptoms like dry mouth, dilated pupils, rapid heart rate, and delirium, and were treated successfully with supportive measures.
- The toxicity's severity can vary, potentially causing severe reactions such as seizures and coma; awareness and prompt treatment are crucial, with options like physostigmine available for extreme cases.
[Belladonna (Atropine), in The Labours of Hercules].
Brain Nerve
December 2023
Department of Neurology, Nankoku Hosiptal.
The Labours of Hercules, written by Agatha Christie, contains twelve short stories, with 'atropine' playing a crucial role in the seventh story, The Cretan Bull (1939). Atropine easily crosses the blood-brain barrier (BBB), leading to central nervous system (CNS) side effects such as delirium, hallucinations, disorientation, memory problems, coma or stupor, and convulsive seizures when overdosed. In this episode, a concentrated form of atropine obtained from prescribed eye drops was misused to induce a hereditary incurable neurodegenerative disorder, similar to Huntington's Chorea, in the client's fiancée.
View Article and Find Full Text PDFAntiviral and anti-inflammatory activity of novel belladonna formulation against Japanese encephalitis virus via inhibition of p65 nuclear translocation and TNF-α mediated NF-kB signaling.
Biotechnol Genet Eng Rev
October 2023
Department of Medicine, JSPS Government Medical College, Hyderabad, India.
Japanese encephalitis (JE) is a mosquito-borne flavivirus infection, a major cause of viral encephalitis in South-East Asia with a CFR of ~30% and no specific treatment. Therefore, a novel belladonna formulation (BCT) was prepared and its antiviral and anti-inflammatory activity was elucidated during Japanese encephalitis virus (JEV) infection. Anti-JEV role of BCT was investigated aiming to prevent the infection in the peripheral immune cells.
View Article and Find Full Text PDFIntradetrusor OnabotuliniumtoxinA injection for refractory bladder spasms before vesicovaginal fistula repair.
Urol Case Rep
January 2023
Beaumont Health, Royal Oak, MI, USA.
This is a report of a women who failed 2 surgical repairs of vesicovaginal fistula secondary to refractory bladder spasms. After each surgical procedure - the hysterectomy and subsequent fistula repairs - the patient reported severe bladder spasms refractory to medical management. Our treatment was intradetrusor onabotuliniumtoxinA injections 4 weeks prior to a planned surgical fistula repair.
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