Progestin megestrol acetate treatment of 160 postmenopausal women with progressive metastatic breast cancer is evaluated. Objective remission was found in 48 patients (30%) and stabilization of disease occurred in 58 (36%) cases. In each of these response categories, the median time interval before subsequent progression took place was nine months. Patients with a postmenopausal age of more than five years showed a significantly higher remission rate than did younger patients. In addition, great differences in remission rates were apparent between groups of patients classified according to dominant sites and separate sites of lesions. The length of disease-free interval did not prove to be of great importance in predicting the remission. No great difference in remission rates were found between patients treated with megestrol acetate as the first hormonal treatment and those previously treated with hormones. Side effects were negligible; a moderate weight increase without demonstrated fluid retention was found during therapy in 10% of the cases. Toxicity was not encountered. Megestrol acetate therapy may be the first choice of treatment in late postmenopausal patients with soft tissue and lung metastases.
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http://dx.doi.org/10.1002/1097-0142(19801201)46:11<2369::aid-cncr2820461111>3.0.co;2-3 | DOI Listing |
BMJ Case Rep
January 2025
Neurosurgery, CHU de Liege Hospital Sart Tilman, Liege, Belgium
Meningioma regression after progestin treatment interruption is already established. Zoely is a combined oral contraceptive including oestradiol and progestin (nomegestrol acetate). The effect of combined oestrogen with nomegestrol acetate on meningioma is currently unknown.
View Article and Find Full Text PDFCurr Opin Obstet Gynecol
December 2024
Mount Sinai Medical Center, Miami Beach, Florida, USA.
Purpose Of Review: Endometrial cancer (EC) is rising in incidence, particularly in younger, premenopausal women, due to increasing rates of obesity and delayed childbearing. This review evaluates current and emerging endocrine therapies, with a focus on fertility-preserving approaches for early-stage EC and treatment options for advanced or recurrent disease.
Recent Findings: Fertility-sparing endocrine therapies, such as medroxyprogesterone acetate, megestrol acetate, and levonorgestrel-releasing intrauterine devices, achieve high response rates but carry recurrence risks.
Gynecol Oncol
January 2025
Department of Gynecology with Center of Oncological Surgery, Universitätsklinik Charité, Campus Virchow Klinikum, Berlin, Germany.
Purpose: The CDK4/6 inhibitor palbociclib inhibits cyclin A, which is overexpressed in endometrial cancer. Combining palbociclib with endocrine therapy improves efficacy in hormone receptor-positive breast cancer. We investigated palbociclib combined with endocrine therapy for estrogen receptor-positive advanced/recurrent endometrial cancer.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
November 2024
Department of Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Immun Inflamm Dis
November 2024
Department of Gynecology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Background: Cervical cancer is one of the most common malignancies among women. Vesicle-mediated transport mechanisms significantly influence tumor cell behavior through intercellular material exchange. However, prognostic significance in CC patients remains underexplored.
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