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Severe bupropion intoxication successfully treated with resin adsorber haemoperfusion.
Nephrology (Carlton)
January 2025
Excellence Centre for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Bupropion is used as smoking cessation drug and antidepressant. Drug overdose has multi-system involvement including neurotoxicity and cardiovascular collapse. Use of haemoperfusion in bupropion toxicity is generally not useful, however in life-threatening condition it could be a life saver.
View Article and Find Full Text PDFResearch progress on blood compatibility of hemoperfusion adsorbent materials.
Front Bioeng Biotechnol
October 2024
Department of Cardiovascular Surgery, Gaozhou People's Hospital, Gaozhou, Guangdong, China.
This comprehensive review examines the latest developments in improving the blood compatibility of hemoperfusion adsorbents. By leveraging advanced coating and modification techniques, including albumin-collodion, cellulose, hydrogel, and heparin coatings, notable enhancements in blood compatibility have been achieved across diverse adsorbent types, such as carbon-based, resin-based, and polysaccharide-based materials. Despite promising laboratory results, the intricate manufacturing processes and elevated costs present significant challenges for broad clinical application.
View Article and Find Full Text PDFHigh adsorption capacity of hemoperfusion on imipenem in critically ill patients with septic shock: a case report.
BMC Infect Dis
August 2024
Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.
Article Synopsis
- Sepsis is a serious condition where the body's response to infection causes organ dysfunction, and hemoperfusion is being used to filter out harmful inflammatory cytokines from the blood.
- In a case study, a 69-year-old man with diabetes developed Multiple Organ Dysfunction Syndrome suspected to be due to septic shock, requiring intensive treatment including broad-spectrum antibiotics and hemoperfusion.
- The treatment showed that hemoperfusion significantly reduced the levels of the antibiotic imipenem in the bloodstream, highlighting the need for additional doses before the procedure to ensure effective antibiotic therapy.
Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion.
Polymers (Basel)
June 2024
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
Efficient adsorbents for excess bilirubin removal are extremely important for the treatment of hyperbilirubinemia. However, traditional adsorbents, such as activated carbons and ion-exchange resins, still suffer from dissatisfactory adsorption performance and poor blood compatibility. Herein, we adopted a rational design strategy guided by density functional theory (DFT) calculations to prepare blood-compatible quaternary ammonium group grafted electrospun polyacrylonitrile nanofiber adsorbents.
View Article and Find Full Text PDFAssessment of triglyceride clearance of haemoperfusion from three cases of hypertriglyceridaemia-induced acute pancreatitis: a case series.
J Int Med Res
May 2024
Department of Intensive Care and Emergency Medicine, The Third Hospital of Xiamen, Xiamen, Fujian Province, China.
Rapid reduction of plasma triglycerides (TG) is believed to improve the outcome of pancreatitis in the context of hypertriglyceridaemia (HTG)-induced acute pancreatitis (HTG-AP). Previous studies have suggested that haemoperfusion (HP) with the Jafron cartridge series could be effective for reducing TG concentrations in patients with HTG-AP. However, the clearance capacity (CC) for TG removal has not been reported.
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